| Differential SP220K expression in renal carcinoma and oncocytoma cells. | |
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MedLine Citation:
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PMID: 9311589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SP220K is a newly described serine proteinase which displays guanidinobenzoatase activity in its inactive form and gelatinolytic activity in its active form. SP220K expression was studied in 20 renal clear-cell carcinomas and in a series of renal oncocytomas, a rare benign tumor derived from the kidney tubule epithelium. We provide evidence that SP220K expression, as assessed by guanidinobenzoatase activity, gelatin zymography and Western blot immunodetection, was increased markedly in cancer basolateral membranes compared to kidney cortex controls, whereas no signal was detectable in basolateral membranes from the 5 renal oncocytomas studied. Cytoplasms of carcinoma cells were immunodetected consistently, whereas no expression was seen in oncocytic cells from any of the oncocytomas studied (12/12). Endothelial cells were immunodetected in all 3 tissue types. Our data favor a potential mechanistic relationship between expression of the matrix proteinase SP220K and invasive phenotype in kidney epithelium proliferative processes. |
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Authors:
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S Thaon; C Ferrero; P Auberger; J F Michiels; D Droz; J Amiel; B Rossi; C Poustis-Delpont |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: 72 ISSN: 0020-7136 ISO Abbreviation: Int. J. Cancer Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-10-31 Completed Date: 1997-10-31 Revised Date: 2007-07-24 |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 752-7 Citation Subset: IM |
Affiliation:
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Laboratoire de Biochimie, Faculte de Medecine, Nice, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma, Oxyphilic
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enzymology*,
metabolism Blotting, Western Carboxylic Ester Hydrolases / metabolism Carcinoma, Renal Cell / enzymology*, metabolism Cell Membrane / enzymology Cytoplasm / enzymology Endopeptidases / metabolism Gelatinases / metabolism Humans Immunohistochemistry Kidney Cortex / enzymology Kidney Neoplasms / enzymology*, metabolism Serine Endopeptidases / metabolism* |
| Chemical | |
Reg. No./Substance:
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EC 3.1.1.-/Carboxylic Ester Hydrolases; EC 3.1.1.-/guanidinobenzoate esterase; EC 3.4.-/Endopeptidases; EC 3.4.21.-/SP220K cell surface matrix proteinase; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.24.-/Gelatinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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