Document Detail

Differential SP220K expression in renal carcinoma and oncocytoma cells.
MedLine Citation:
PMID:  9311589     Owner:  NLM     Status:  MEDLINE    
SP220K is a newly described serine proteinase which displays guanidinobenzoatase activity in its inactive form and gelatinolytic activity in its active form. SP220K expression was studied in 20 renal clear-cell carcinomas and in a series of renal oncocytomas, a rare benign tumor derived from the kidney tubule epithelium. We provide evidence that SP220K expression, as assessed by guanidinobenzoatase activity, gelatin zymography and Western blot immunodetection, was increased markedly in cancer basolateral membranes compared to kidney cortex controls, whereas no signal was detectable in basolateral membranes from the 5 renal oncocytomas studied. Cytoplasms of carcinoma cells were immunodetected consistently, whereas no expression was seen in oncocytic cells from any of the oncocytomas studied (12/12). Endothelial cells were immunodetected in all 3 tissue types. Our data favor a potential mechanistic relationship between expression of the matrix proteinase SP220K and invasive phenotype in kidney epithelium proliferative processes.
S Thaon; C Ferrero; P Auberger; J F Michiels; D Droz; J Amiel; B Rossi; C Poustis-Delpont
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  72     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-31     Completed Date:  1997-10-31     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  752-7     Citation Subset:  IM    
Laboratoire de Biochimie, Faculte de Medecine, Nice, France.
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MeSH Terms
Adenoma, Oxyphilic / enzymology*,  metabolism
Blotting, Western
Carboxylic Ester Hydrolases / metabolism
Carcinoma, Renal Cell / enzymology*,  metabolism
Cell Membrane / enzymology
Cytoplasm / enzymology
Endopeptidases / metabolism
Gelatinases / metabolism
Kidney Cortex / enzymology
Kidney Neoplasms / enzymology*,  metabolism
Serine Endopeptidases / metabolism*
Reg. No./Substance:
EC 3.1.1.-/Carboxylic Ester Hydrolases; EC 3.1.1.-/guanidinobenzoate esterase; EC 3.4.-/Endopeptidases; EC 3.4.21.-/SP220K cell surface matrix proteinase; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.24.-/Gelatinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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