| Differential Response in Left Ventricular Mass and Arterial Resistive Index following Fosinopril Therapy. | |
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MedLine Citation:
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PMID: 18370474 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The aim of this study was to assess the differential response in left ventricular mass and resistive index (RI) of renal and carotid arteries in mild to moderate essential hypertensive patients after 1 year of ACE inhibitor therapy. Twenty-six patients (mean age 42.9 +/- 10.9 years) underwent 24-hour ambulatory blood pressure monitoring, echocardiography and renal and carotid echo-Doppler (by measuring RI, as an expression of arterial impedance) after a placebo period and 12 months of fosinopril treatment (20 mg/day). Our study showed a significant decrease in 24-hour BP (p < 0.05), left cardiac mass (p < 0.05) and RI of common carotid and hilum renal arteries (p < 0.05). In contrast, there were no significant reductions in the interlobar renal RI (as an expression of unchanged intrarenal resistance) and in the internal carotid artery RI. While the 24-hour BP decrease was strongly correlated with the left cardiac mass modifications (r = 0.73, p < 0.005), no significant relationship was observed with the renal and carotid artery parameters. In conclusion, the present study demonstrated that long-term treatment with fosinopril produced a differential response in left ventricular mass and arterial RI in patients with mild to moderate essential hypertension. In addition, the arterial impedance modifications of common carotid and hilum renal artery were largely unrelated to the 24-hour BP reduction. |
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Authors:
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F Veglio; L Gastaldi; M Frascisco; L Coda; R Melchio; F Rabbia; L Chiandussi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical drug investigation Volume: 15 ISSN: 1173-2563 ISO Abbreviation: Clin Drug Investig Publication Date: 1998 |
Date Detail:
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Created Date: 2008-03-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504817 Medline TA: Clin Drug Investig Country: New Zealand |
Other Details:
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Languages: eng Pagination: 101-9 Citation Subset: - |
Affiliation:
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Department of Medicine and Experimental Oncology, University of Turin, Turin, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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