| Differential, LFA-1-sensitive effects of antibodies to nectadrin, the heat-stable antigen, on B lymphoblast aggregation and signal transduction. | |
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MedLine Citation:
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PMID: 8117278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nectadrin, the heat-stable antigen (HSA), is a highly glycosylated GPI-linked glycoprotein that can undergo homophilic and heterophilic binding. In the present work we have examined short-term effects of nectadrin antibodies on splenic B lymphoblast aggregation and signal transduction. Monoclonal antibody 79 inhibited cell aggregation and induced an intracellular Ca++ signal in the absence of cross-linking. Both these effects were perturbed in the presence of LFA-1 antibodies. Nectadrin antibody M1/69 and polyclonal nectadrin antibodies stimulated cell aggregation, did not induce a Ca++ signal, and their effects were functionally independent of LFA-1. These results suggest that nectadrin may concomitantly mediate primary and activate secondary adhesion mechanisms whereby each of these processes may be related to a different signal transduction pathway. |
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Authors:
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G Kadmon; F von Bohlen und Halbach; M Schachner; P Altevogt |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 198 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1994 Feb |
Date Detail:
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Created Date: 1994-03-29 Completed Date: 1994-03-29 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1209-15 Citation Subset: IM |
Affiliation:
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Department of Cellular Immunology 710, German Cancer Research Center, Heidelberg. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies / pharmacology* Antibodies, Monoclonal / pharmacology* Antigens, CD / immunology, physiology* Antigens, CD24 B-Lymphocytes / cytology, drug effects, physiology* Calcium / metabolism* Cell Aggregation / drug effects Cells, Cultured Glycosylphosphatidylinositols / metabolism Lipopolysaccharides / pharmacology Lymphocyte Function-Associated Antigen-1 / immunology, pharmacology* Membrane Glycoproteins* Mice Mice, Inbred DBA Salmonella enteritidis Signal Transduction / drug effects* Spleen / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Antibodies, Monoclonal; 0/Antigens, CD; 0/Antigens, CD24; 0/Cd24a protein, mouse; 0/Glycosylphosphatidylinositols; 0/Lipopolysaccharides; 0/Lymphocyte Function-Associated Antigen-1; 0/Membrane Glycoproteins; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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