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Differential Expression of CXC Chemokines CXCL10 and CXCL12 in Term and Pre-term Neonates and Their Mothers.
MedLine Citation:
PMID:  22738089     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND AND AIM: Pre-term delivery is a mostly unknown frequent disorder worldwide. This project aimed to investigate the circulating levels of CXCL12 (SDF-1) and CXCL10 (IP-10) in cord blood of term and pre-term delivered fetuses and their corresponding mothers. MATERIAL AND METHODS: Cord and peripheral blood samples were collected from 50 pre-term and 50 term infants and their mothers. Serum levels of CXCL12 and CXCL10 were measured by ELISA. RESULTS: The findings of this study indicated that the circulating levels of CXCL10 were elevated in mothers bearing pre-term infants, while CXCL12 was only increased in pre-term infants. CONCLUSION: The results suggested that the pathophysiological status of both mother and infant are involved in prematurity. Moreover, these findings suggest an inflammatory response in pre-term labor, which probably is controlled by inducible chemokines such as CXCL10.
Authors:
Fariba Aminzadeh; Zohreh Ghorashi; Saeedeh Nabati; Mohsen Ghasemshirazi; Mohammad Kazemi Arababadi; Ali Shamsizadeh; Mojgan Noroozi Karimabad; Hossein Khorramdelazad; Shokoofeh Darakhshan; Gholamhossein Hassanshahi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-28
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  -     ISSN:  1600-0897     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Department of Gynecology Surgery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
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