| Differential Effects of Treadmill Exercise in Early and Chronic Diabetic Stages on Parvalbumin Immunoreactivity in the Hippocampus of a Rat Model of Type 2 Diabetes. | |
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MedLine Citation:
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PMID: 21516442 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In the present study, we investigated the effects of treadmill exercise in early and chronic diabetic stages on parvalbumin (PV) immunoreactivity in the subgranular zone of the dentate gyrus of Zucker diabetic fatty (ZDF) and its lean control rats (ZLC). To investigate the effects, ZLC and ZDF rats at 6 or 23 weeks of age were put on a treadmill with or without running for 1 h/day/5 consecutive days at 16-22 m/min for 5 weeks or 12-16 m/min for 7 weeks, respectively. Physical exercise in pre-diabetic rats prevented onset of diabetes, while exercise in rats at chronic diabetic stage significantly reduced blood glucose levels. In addition, physical exercise in the pre-diabetic rats significantly increased PV immunoreactive fibers in the strata oriens and radiatum of the CA1-3 region and in the polymorphic and molecular layers of the dentate gyrus compared to that in sedentary controls. However, in rats at chronic stages, PV immunoreactivity was slightly increased in the CA1-3 region as well as in the dentate gyrus compared to that in the sedentary controls. These results suggest that physical exercise has differential effects on blood glucose levels and PV immunoreactivity according to diabetic stages. Early exercise improves diabetic phenotype and PV immunoreactive fibers in the rat hippocampus. |
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Authors:
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In Koo Hwang; Sun Shin Yi; Ki-Yeon Yoo; Ok Kyu Park; Bingchun Yan; Wook Song; Moo-Ho Won; Yeo Sung Yoon; Je Kyung Seong |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-24 |
Journal Detail:
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Title: Neurochemical research Volume: - ISSN: 1573-6903 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Anatomy and Cell Biology College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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