Document Detail


Differential effects of rosiglitazone and metformin on postprandial lipemia in patients with HIV-lipodystrophy.
MedLine Citation:
PMID:  20947819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare the effects of rosiglitazone (8 mg/d, n=19) and metformin (2 g/d, n=18) on postprandial lipemia in patients with HIV-lipodystrophy.
METHODS AND RESULTS: Lipodystrophy in HIV is associated with insulin resistance and disturbed postprandial triglyceride and free fatty acid (FFA) metabolism. We conducted an open randomized 6-month study with standardized 10-h oral fat-loading tests at baseline and after treatment. Rosiglitazone (-34%) and metformin (-37%) reduced homeostasis model assessment similarly (P<0.05). Rosiglitazone did not change the area under the curve for FFA and triglyceride; however, it did reduce the area under the curve for hydroxybutyric acid (a marker of hepatic FFA oxidation) by 25% (P<0.05). Rosiglitazone increased the area under the curve for remnantlike particle cholesterol by 40% (P<0.01) compared with baseline. Metformin did not change any of the postprandial measurements.
CONCLUSIONS: Rosiglitazone improved insulin sensitivity and decreased postprandial hydroxybutyric acid levels in patients with HIV-lipodystrophy, suggesting improved FFA handling. Despite metabolic improvements, rosiglitazone caused a marked increase in postprandial remnantlike particle cholesterol, which may adversely affect cardiovascular risk. Metformin did not affect postprandial lipemia and could be used to treat insulin resistance in this population.
Authors:
Jeroen P H van Wijk; Andy I M Hoepelman; Eelco J P de Koning; Geesje Dallinga-Thie; Ton J Rabelink; Manuel Castro Cabezas
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2010-10-14
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  31     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-16     Completed Date:  2011-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  228-33     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, St Franciscus Gasthuis Rotterdam, 3004 BA Rotterdam, the Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Area Under Curve
Biological Markers / blood
Cholesterol / blood
Fatty Acids, Nonesterified / blood
HIV-Associated Lipodystrophy Syndrome / blood,  drug therapy*
Humans
Hydroxybutyrates / blood
Hyperlipidemias / blood,  drug therapy*
Hypoglycemic Agents / adverse effects,  therapeutic use*
Insulin Resistance
Male
Metformin / therapeutic use*
Middle Aged
Netherlands
Postprandial Period
Prospective Studies
Thiazolidinediones / adverse effects,  therapeutic use*
Time Factors
Treatment Outcome
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids, Nonesterified; 0/Hydroxybutyrates; 0/Hypoglycemic Agents; 0/Thiazolidinediones; 0/Triglycerides; 122320-73-4/rosiglitazone; 57-88-5/Cholesterol; 657-24-9/Metformin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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