| Differential effects of intraventricular hemorrhage and white matter injury on preterm cerebellar growth. | |
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MedLine Citation:
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PMID: 20961562 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To hypothesize that detailed examination of early cerebellar volumes in time would distinguish differences in cerebellar growth associated with intraventricular hemorrhage (IVH) and white matter injury in preterm infants. STUDY DESIGN: Preterm newborns at the University of California San Francisco (n = 57) and the University of British Columbia (n = 115) were studied with serial magnetic resonance imaging scans near birth and again at near term-equivalent age. Interactive semi-automated tools were used to determine volumes of the cerebellar hemispheres. RESULTS: Adjusting for supratentorial brain injury, cerebellar hemorrhage, and study site, cerebellar volume increased 1.7 cm(3)/week postmenstrual age (95% CI, 1.6-1.7; P < .001). More severe supratentorial IVH was associated with slower growth of cerebellar volumes (P < .001). Volumes by 40 weeks were 1.4 cm(3) lower in premature infants with grade 1 to 2 IVH and 5.4 cm(3) lower in infants with grade 3 to 4 IVH. The same magnitude of decrease was found between ipsilateral and contralateral IVH. No association was found with severity of white matter injury (P = .3). CONCLUSIONS: Early effects of decreased cerebellar volume associated with supratentorial IVH in either hemisphere may be a result of concurrent cerebellar injury or direct effects of subarachnoid blood on cerebellar development. |
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Authors:
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Emily W Y Tam; Steven P Miller; Colin Studholme; Vann Chau; David Glidden; Kenneth J Poskitt; Donna M Ferriero; A James Barkovich |
Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-20 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 158 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-14 Completed Date: 2011-04-05 Revised Date: 2013-03-22 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 366-71 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Neurology, University of California San Francisco, CA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain Injuries
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pathology* Cerebellum / blood supply, growth & development*, injuries Cerebral Ventricles* Female Humans Imaging, Three-Dimensional Infant, Newborn Infant, Premature* Intracranial Hemorrhages / pathology* Leukoencephalopathies / pathology* Longitudinal Studies Magnetic Resonance Imaging Male Organ Size Regression Analysis |
| Grant Support | |
ID/Acronym/Agency:
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CHI 151135//Canadian Institutes of Health Research; R01 NS046432/NS/NINDS NIH HHS; R01 NS046432-07/NS/NINDS NIH HHS; R01 NS046432-08/NS/NINDS NIH HHS; R01 NS346432/NS/NINDS NIH HHS; UL1 RR024131/RR/NCRR NIH HHS; UL1 RR024131/RR/NCRR NIH HHS; UL1 RR024131-05/RR/NCRR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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