Document Detail

Differential effects of intraventricular hemorrhage and white matter injury on preterm cerebellar growth.
MedLine Citation:
PMID:  20961562     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To hypothesize that detailed examination of early cerebellar volumes in time would distinguish differences in cerebellar growth associated with intraventricular hemorrhage (IVH) and white matter injury in preterm infants.
STUDY DESIGN: Preterm newborns at the University of California San Francisco (n = 57) and the University of British Columbia (n = 115) were studied with serial magnetic resonance imaging scans near birth and again at near term-equivalent age. Interactive semi-automated tools were used to determine volumes of the cerebellar hemispheres.
RESULTS: Adjusting for supratentorial brain injury, cerebellar hemorrhage, and study site, cerebellar volume increased 1.7 cm(3)/week postmenstrual age (95% CI, 1.6-1.7; P < .001). More severe supratentorial IVH was associated with slower growth of cerebellar volumes (P < .001). Volumes by 40 weeks were 1.4 cm(3) lower in premature infants with grade 1 to 2 IVH and 5.4 cm(3) lower in infants with grade 3 to 4 IVH. The same magnitude of decrease was found between ipsilateral and contralateral IVH. No association was found with severity of white matter injury (P = .3).
CONCLUSIONS: Early effects of decreased cerebellar volume associated with supratentorial IVH in either hemisphere may be a result of concurrent cerebellar injury or direct effects of subarachnoid blood on cerebellar development.
Emily W Y Tam; Steven P Miller; Colin Studholme; Vann Chau; David Glidden; Kenneth J Poskitt; Donna M Ferriero; A James Barkovich
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-10-20
Journal Detail:
Title:  The Journal of pediatrics     Volume:  158     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-14     Completed Date:  2011-04-05     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  366-71     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Mosby, Inc. All rights reserved.
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MeSH Terms
Brain Injuries / pathology*
Cerebellum / blood supply,  growth & development*,  injuries
Cerebral Ventricles*
Imaging, Three-Dimensional
Infant, Newborn
Infant, Premature*
Intracranial Hemorrhages / pathology*
Leukoencephalopathies / pathology*
Longitudinal Studies
Magnetic Resonance Imaging
Organ Size
Regression Analysis
Grant Support
CHI 151135//Canadian Institutes of Health Research; R01 NS046432/NS/NINDS NIH HHS; R01 NS046432-07/NS/NINDS NIH HHS; R01 NS346432/NS/NINDS NIH HHS; UL1 RR024131/RR/NCRR NIH HHS; UL1 RR024131/RR/NCRR NIH HHS; UL1 RR024131-05/RR/NCRR NIH HHS

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