| Differential effects of high-carbohydrate and high-fat diet composition on muscle insulin resistance in rats. | |
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MedLine Citation:
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PMID: 20592898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was conducted to evaluate whether the composition of carbohydrate or fat diet affects insulin resistance by measuring the muscle glucose transport rate. Both high-sucrose and high-starch diet with or without high-fat decreased insulin-stimulated glucose transport, but there were no significant differences among groups. Calorie intake in both high-sucrose and high-starch diet groups was higher than in chow group. The high-fat high-sucrose diet induced decrease in insulin-stimulated glucose transport was partially improved by supplement with fish oil. Calorie intake in high-fat high-sucrose and fish oil supplemented groups was higher than in chow group. The decreased insulin-stimulated glucose transport was accompanied by the increase in visceral fat mass, plasma triglyceride and insulin levels. These changes were improved by the supplement with fish oil. These results demonstrate that the composition of fat in diet is clearly instrumental in the induction of muscle insulin resistance. However, in high carbohydrate diet, it is likely that the amount of calorie intake may be a more important factor in causing insulin resistance than the composition of carbohydrate. Thus, the compositions of carbohydrate and fat in diet differentially affect on muscle insulin resistance. |
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Authors:
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Mu-Ryun Chun; Youn Ju Lee; Ki-Hoon Kim; Yong-Woon Kim; So-Young Park; Keun-Mi Lee; Jong-Yeon Kim; Yoon-Ki Park |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-17 |
Journal Detail:
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Title: Journal of Korean medical science Volume: 25 ISSN: 1598-6357 ISO Abbreviation: J. Korean Med. Sci. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-01 Completed Date: 2010-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703518 Medline TA: J Korean Med Sci Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 1053-9 Citation Subset: IM |
Affiliation:
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Obesity-Diabetes Advanced Research Center, School of Medicine, Yeungnam University, Daegu, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism Body Weight Diet Dietary Carbohydrates / pharmacology* Dietary Fats / pharmacology* Dietary Supplements Energy Intake / drug effects Fish Oils / pharmacology Insulin / blood Insulin Resistance / physiology* Intra-Abdominal Fat / drug effects, metabolism Male Muscle, Skeletal / drug effects*, physiology Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Fish Oils; 11061-68-0/Insulin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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