Document Detail


Differential effects of dopamine receptor D1-type and D2-type antagonists and phase of the estrous cycle on social learning of food preferences, feeding, and social interactions in mice.
MedLine Citation:
PMID:  21525863     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The neurobiological bases of social learning, by which an animal can 'exploit the expertise of others' and avoid the disadvantages of individual learning, are only partially understood. We examined the involvement of the dopaminergic system in social learning by administering a dopamine D1-type receptor antagonist, SCH23390 (0.01, 0.05, and 0.1 mg/kg), or a D2-type receptor antagonist, raclopride (0.1, 0.3, and 0.6 mg/kg), to adult female mice prior to socially learning a food preference. We found that while SCH23390 dose-dependently inhibited social learning without affecting feeding behavior or the ability of mice to discriminate between differently flavored diets, raclopride had the opposite effects, inhibiting feeding but leaving social learning unaffected. We showed that food odor, alone or in a social context, was insufficient to induce a food preference, proving the specifically social nature of this paradigm. The estrous cycle also affected social learning, with mice in proestrus expressing the socially acquired food preference longer than estrous and diestrous mice. This suggests gonadal hormone involvement, which is consistent with known estrogenic regulation of female social behavior and estrogen receptor involvement in social learning. Furthermore, a detailed ethological analysis of the social interactions during which social learning occurs showed raclopride- and estrous phase-induced changes in agonistic behavior, which were not directly related to effects on social learning. Overall, these results suggest a differential involvement of the D1-type and D2-type receptors in the regulation of social learning, feeding, and agonistic behaviors that are likely mediated by different underlying states.
Authors:
Elena Choleris; Amy E Clipperton-Allen; Durene G Gray; Sebastian Diaz-Gonzalez; Robert G Welsman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-04-27
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  36     ISSN:  1740-634X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-15     Completed Date:  2012-03-22     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  1689-702     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of Guelph, Guelph, ON, Canada. echoleri@uoguelph.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Dopamine Antagonists / pharmacology
Estrous Cycle / drug effects,  physiology*
Feeding Behavior / drug effects,  physiology*
Female
Food Preferences / drug effects,  physiology*
Mice
Receptors, Dopamine D1 / antagonists & inhibitors*,  physiology
Receptors, Dopamine D2 / antagonists & inhibitors*,  physiology
Social Behavior*
Chemical
Reg. No./Substance:
0/Dopamine Antagonists; 0/Receptors, Dopamine D1; 0/Receptors, Dopamine D2
Comments/Corrections

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