| Differential effects of clinical doses of antenatal betamethasone on nephron endowment and glomerular filtration rate in adult sheep. | |
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MedLine Citation:
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PMID: 19897787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antenatal steroid administration is associated with alterations in fetal kidney development and hypertension. However, a causal relationship between nephron deficit and hypertension has not been established. In this study, we measured nephron number, renal function, and blood pressure in sheep exposed antenataly to betamethasone. Pregnant sheep were given 2 betamethasone doses (0.17 mg/kg) or vehicle at 80 and 81 days gestational age and allowed to deliver at term. Data were obtained from a fetal cohort and 2 adult cohorts and were analyzed by analysis of variance (ANOVA) and/or 2 sample t test. Antenatal betamethasone induced a 26% reduction in the number of nephrons in both males and females in the absence of intrauterine growth restriction and/or prematurity. Adult males presented a reduction in glomerular filtration rate (GFR; 132 +/- 12.7 vs 114 +/- 7.0 mL/min, P < .05). Betamethasone administration was also associated with an increase in arterial blood pressure of similar magnitude in male (mean arterial pressure [MAP] in mm Hg; 98 +/- 2.7 vs 105 +/- 2.4) and female (96 +/- 1.9 vs 105 +/- 2.4) adult sheep and the increase in blood pressure preceded the decrease in GFR in the males. Furthermore, we found no significant association between the magnitude of the decrease in nephron number and the magnitude of the increase in arterial blood pressure. Our data thus support the conclusion that exposure to glucocorticoids at a time of rapid kidney growth is associated with an elevation in blood pressure that does not appear related solely to the reduction in nephron number. |
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Authors:
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Jie Zhang; G Angela Massmann; James C Rose; Jorge P Figueroa |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-11-06 |
Journal Detail:
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Title: Reproductive sciences (Thousand Oaks, Calif.) Volume: 17 ISSN: 1933-7205 ISO Abbreviation: Reprod Sci Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-04 Completed Date: 2010-04-22 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 101291249 Medline TA: Reprod Sci Country: United States |
Other Details:
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Languages: eng Pagination: 186-95 Citation Subset: IM |
Affiliation:
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Perinatal Research Laboratory, Department of Obstetrics and Gynecology, Center for Research in Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Betamethasone / pharmacology* Blood Pressure / drug effects Dose-Response Relationship, Drug Female Gestational Age Glomerular Filtration Rate / drug effects Glucocorticoids / pharmacology* Hypertension, Renal / chemically induced*, pathology, physiopathology Inulin / diagnostic use Kidney Function Tests Male Nephrons / abnormalities*, pathology, physiology Pregnancy Prenatal Exposure Delayed Effects / pathology*, physiopathology Sheep p-Aminohippuric Acid / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
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HL 68728/HL/NHLBI NIH HHS; P01HD04784/HD/NICHD NIH HHS; R01 HD017644-25/HD/NICHD NIH HHS; R01 HL068728-07/HL/NHLBI NIH HHS; R01 HL068728-08/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 378-44-9/Betamethasone; 61-78-9/p-Aminohippuric Acid; 9005-80-5/Inulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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