| The Differential Effect of Risperidone and Olanzapine on Insulin Sensitivity after 3 Weeks of Treatment: A HOMA Pilot Study. | |
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MedLine Citation:
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PMID: 22174030 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Patients with an acute psychotic episode underwent HOMA testing for insulin sensitivity (IS) prior to and after 3 weeks of treatment with olanzapine (n=7) or risperidone (n=7).The HOMA-IS index was reduced in the olanzapine group, but significantly increased in patients treated with risperidone. There was a significant "time×medication" interaction (p=0.03). The BMI significantly increased as a result of both treatments. IS can be acutely ameliorated by antipsychotic treatment with risperidone despite weight increase.Compared to risperidone, the IS is impaired after a 3-week treatment with olanzapine. Already short-term antipsychotic treatment may have effects on insulin sensitivity. |
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Authors:
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G Paslakis; M Deuschle; J Thome; S Rüße; D Kopf |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-15 |
Journal Detail:
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Title: Pharmacopsychiatry Volume: - ISSN: 1439-0795 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8402938 Medline TA: Pharmacopsychiatry Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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Department of Psychiatry and Psychotherapy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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