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Differential Effect of Insulin Like Growth Factor-I on Constriction of Human Uterine and Placental Arteries.
MedLine Citation:
PMID:  22948758     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Context:Discrete regulation of the uterine and placental vasculatures is an important feature of uteroplacental perfusion and pregnancy success because appropriate maternal/fetal exchange of nutrients and gases is crucial for normal fetal growth. Placental vasculature lacks autonomic innervation so tone is controlled by locally derived vasoactive factors. IGF-I, which is produced by the placenta, is critical for normal fetal growth and studies of animal vascular systems have shown that IGF-I regulates vasomotor tone.Objective:The objective of the study was to determine whether IGF-I directly alters human placental and myometrial arterial tone in vitro.Participants:Women with uncomplicated pregnancy delivering a singleton infant at term participated in the study.Setting:The study was conducted at university hospital laboratories.Main Outcome Measure(s):Comparison of arterial tension measured before and after exposure to IGF-I.Design:Placental and myometrial arteries were mounted on a wire myograph, exposed to the constrictor U46619 (10(-10) to 10(-5) m), returned to baseline tension, and then incubated with IGF-I (0-500 ng/ml) for various time points before performing a second dose-response curve to U46619. IGF-I receptor protein expression was assessed.Results:IGF-I did not acutely alter the response of placental arteries to U46619. Exposure of myometrial arteries to IGF-I caused a rightward shift of U46619 dose-response curves (P < 0.05); EC(50) data were significantly increased at 30 (15.5 ± 2.8 vs. 133 ± 44 nm, before and after IGF treatment, respectively) and 60 min (10.9 ± 1.9 vs. 146 ± 47 nm). Placental and myometrial arteries had a similar IGF-I receptor expression profile.Conclusions:IGF-I acutely modulates the vasomotor tone of human myometrial, but not placental, arteries, suggesting that IGF-I regulates the delivery of maternal blood to the placenta.
Authors:
Jemma J Corcoran; Jayne C Charnock; Julie Martin; Michael J Taggart; Melissa Westwood
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-4
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Maternal and Fetal Health Research Centre (J.J.C., J.C.C., M.W.), University of Manchester, Manchester Academic Health Sciences Centre, St Marys Hospital, Manchester M13 9WL, United Kingdom; and Institute of Cellular Medicine (J.M., M.J.T.), Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.
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