Document Detail

Differential Effect of an Anticholinergic Antidepressant on Sleep-Dependent Memory Consolidation.
MedLine Citation:
PMID:  24790277     Owner:  NLM     Status:  Publisher    
STUDY OBJECTIVES: Rapid eye movement (REM) sleep is considered critical to the consolidation of procedural memory - the memory of skills and habits. Many antidepressants strongly suppress REM sleep, however, and procedural memory consolidation has been shown to be impaired in depressed patients on antidepressant therapy. As a result, it is important to determine whether antidepressive therapy can lead to amnestic impairment. We thus investigated the effects of the anticholinergic antidepressant amitriptyline on sleep-dependent memory consolidation.
DESIGN: Double-blind, placebo-controlled, randomized, parallel-group study.
SETTING: Sleep laboratory.
PARTICIPANTS: Twenty-five healthy men (mean age: 26.8 ± 5.6 y).
INTERVENTIONS: 75 mg amitriptyline versus placebo.
MEASUREMENTS/RESULTS: To test memory consolidation, a visual discrimination task, a finger-tapping task, the Rey-Osterrieth Complex Figure Test, and the Rey Auditory-Verbal Learning Test were performed. Sleep was measured using polysomnography. Our findings show that amitriptyline profoundly suppressed REM sleep and impaired perceptual skill learning, but not motor skill or declarative learning.
CONCLUSIONS: Our study is the first to demonstrate that an antidepressant can affect procedural memory consolidation in healthy subjects. Moreover, considering the results of a recent study, in which selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors were shown not to impair procedural memory consolidation, our findings suggest that procedural memory consolidation is not facilitated by the characteristics of REM sleep captured by visual sleep scoring, but rather by the high cholinergic tone associated with REM sleep. Our study contributes to the understanding of potentially undesirable behavioral effects of amitriptyline.
CITATION: Goerke M, Cohrs S, Rodenbeck A, Kunz D. Differential effect of an anticholinergic antidepressant on sleep-dependent memory consolidation. SLEEP 2014;37(5):977-985.
Monique Goerke; Stefan Cohrs; Andrea Rodenbeck; Dieter Kunz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-1
Journal Detail:
Title:  Sleep     Volume:  37     ISSN:  1550-9109     ISO Abbreviation:  Sleep     Publication Date:  2014  
Date Detail:
Created Date:  2014-5-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7809084     Medline TA:  Sleep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  977-985     Citation Subset:  -    
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