Document Detail


Differential Contributions of Conformation Extension and Domain Unfolding to Properties of Fibronectin Nanotextiles.
MedLine Citation:
PMID:  23043581     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Fibronectin (FN) textiles are built as nanometer-thick fabrics. When uniaxially loaded, these fabrics exhibit a distinct threshold between elastic and plastic deformation with increasing stretch. Fabric mechanics are modeled using an eight-chain network and two-state model, revealing that elastic properties of FN depend on conformational extension of the protein and that plastic deformation depends on domain unfolding. Our results suggest how the molecular architecture of a molecule can be exploited for designer mechanical properties of a bulk material.
Authors:
Leila F Deravi; Tianxiang Su; Jeffrey A Paten; Jeffrey W Ruberti; Katia Bertoldi; Kevin Kit Parker
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-8
Journal Detail:
Title:  Nano letters     Volume:  -     ISSN:  1530-6992     ISO Abbreviation:  Nano Lett.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101088070     Medline TA:  Nano Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering , Boston, Massachusetts 02115, United States.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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