| Different types of renal dysfunction in patients with acute myocardial infarction treated with percutaneous coronary intervention. | |
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MedLine Citation:
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PMID: 17391223 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The prognostic significance of different types of renal dysfunction in patients with acute myocardial infarction (AMI) treated with percutaneous coronary intervention (PCI) has not been well characterized. METHODS: The single-center AMI registry encompassed 1,486 consecutive AMI patients treated with PCI, who were followed by mean 29.7 months. Subjects with an estimated glomerular filtration rate <60 mL/min per 1.73 m2 at baseline were selected (n = 283, 19.0%) and incorporated into the chronic kidney disease (CKD) group. The control group consisted of 1,203 subjects with normal renal function (81.0%). The CKD patients were divided into subgroups: with contrast-induced nephropathy - CKD + CIN (n = 68, 4.6%) and without - CKD-CIN (n = 215, 14.5%). RESULTS: Remote mortality rate was significantly higher in CKD group (34.6%) and in particular subgroups: CKD + CIN (47.0%), CKD-CIN (31.0%) than in controls (9.1%, P < 0.001 for all study groups vs controls). Multivariate analysis identified CKD as an independent predictor of any-cause death in the whole population (hazard ratio [HR] 1.77, 95% confidence interval [CI] 1.60-1.94, P < 0.001). Similarly, CKD + CIN contrary to CKD-CIN had significant and independent influence on remote survival in study population (HR 2.16, 95% CI 1.95-2.37, P < 0.001). CONCLUSIONS: CKD and its types have significant, negative influence on long-term survival in AMI patients treated with PCI. It is especially strongly expressed in those CKD patients who develop contrast-induced nephropathy, which occurrence is an independent risk factor of mortality associated with over twofold increase of death hazard. |
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Authors:
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Jacek Kowalczyk; Radoslaw Lenarczyk; Oskar Kowalski; Beata Sredniawa; Agata Musialik-Lydka; Mariusz Gasior; Lech Polonski; Marian Zembala; Janusz Gumprecht; Zbigniew Kalarus |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of interventional cardiology Volume: 20 ISSN: 0896-4327 ISO Abbreviation: J Interv Cardiol Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-29 Completed Date: 2007-06-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8907826 Medline TA: J Interv Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 143-52 Citation Subset: IM |
Affiliation:
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1st Department of Cardiology, Medical University of Silesia, Silesian Center for Heart Diseases, Zabrze, Poland. jacekmed@poczta.onet.pl |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Angioplasty, Transluminal, Percutaneous Coronary* Case-Control Studies Female Glomerular Filtration Rate Humans Kidney Failure, Chronic / complications*, diagnosis Male Middle Aged Myocardial Infarction / complications*, mortality, therapy* Prognosis Prospective Studies Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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