| Different thermic effects of leptin in adolescent females with varying body fat content. | |
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MedLine Citation:
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PMID: 20452104 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Investigating the effect of leptin on energy expenditure in undernutrition might lead to a better understanding of the role of leptin in regulating body weight in humans. METHODS: 73 underweight female adolescents with anorexia nervosa (AN) were compared with 23 healthy normal weight (nwC), and 9 overweight girls (OW); 37 AN were followed during 7 months of weight recovery. Resting energy expenditure (REE, by indirect calorimetry), body composition (fat mass, FM; lean tissue mass, LTM; by Dual-Energy X-Ray Absorptiometry) and plasma hormones of leptin and 3,5,3'-Triiodothyronine (T(3)) were measured. RESULTS: In underweight, leptin, T(3) and REE adjusted for lean tissue mass (REE(LTM)) were decreased; in OW, FM and leptin were increased at unchanged T(3) and REE(LTM). There was a significant positive relation between FM and leptin at low and normal (AN, r(2) = 0.26; nwC, r(2) = 0.51, p < 0.001), but not at high adiposity. Leptin and REE(LTM) were positively associated in underweight (r(2) = 0.14, p = 0.001) but not in normal or overweight subjects. T(3) was linearly related to REE(LTM) over the whole range of adiposity (r(2) = 0.42, p < 0.001). With weight gain in AN (5.0 ± 3.5 kg) the relationship between leptin and REE(LTM) changed toward the conditions seen in normal weight controls. CONCLUSIONS: At low adiposity the interrelated fall of leptin and REE reflect an adaptive mechanism to preserve body weight. High leptin production associated with excessive adiposity was without effect on metabolic adaptation. |
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Authors:
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Verena K Haas; Kevin J Gaskin; Michael R Kohn; Simon D Clarke; Manfred J Müller |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-07 |
Journal Detail:
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Title: Clinical nutrition (Edinburgh, Scotland) Volume: 29 ISSN: 1532-1983 ISO Abbreviation: Clin Nutr Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-11 Completed Date: 2011-01-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309603 Medline TA: Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 639-45 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. |
Affiliation:
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Department of Adolescent Medicine, The Children's Hospital at Westmead, University of Sydney, Australia. verena.haas@charite.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adipose Tissue / metabolism* Adiposity Adolescent Anorexia Nervosa / metabolism Body Composition* Body Mass Index Calorimetry, Indirect Case-Control Studies Energy Metabolism Female Humans Leptin / blood*, metabolism Linear Models Overweight / metabolism* Rest Thinness / metabolism* Triiodothyronine / blood, metabolism Weight Gain |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 6893-02-3/Triiodothyronine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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