| Different therapeutic responses in chronic obstructive pulmonary disease subgroups. | |
| | |
MedLine Citation:
|
PMID: 21740676 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
SETTING: Eleven referring hospitals in South Korea. OBJECTIVE: To compare therapeutic responses in chronic obstructive pulmonary disease (COPD) subgroups, classified by diffusing capacity of the lung for carbon monoxide (DL(CO)) and lung volume. DESIGN: A total of 130 stable male COPD patients were classified into four subgroups according to baseline DL(CO) and residual volume/total lung capacity (RV/TLC) ratio. We compared therapeutic responses to short acting β(2)-agonist (SABA) and 3-month combined inhalation of long-acting β(2)-agonist (LABA) and corticosteroid among patients with these subgroups. RESULTS: Among the 130 COPD patients, 41 (31.5%) had normal DL(CO) and RV/TLC, 28 (21.5%) low DL(CO) and normal RV/TLC, 31 (23.8%) normal DL(CO) and high RV/TLC, and 30 (23.1%) low DL(CO) and high RV/TLC. The normal DL(CO)/high RV/TLC subgroup showed a significantly larger flow response (changes in forced expiratory volume in 1 s) to salbutamol than the normal DL(CO)/RV/TLC subgroups, and a larger volume response (changes in forced vital capacity) than the two normal RV/TLC subgroups. The normal DL(CO)/high RV/TLC subgroup also showed significantly larger flow and volume response to 3-month combined inhalation of LABA and corticosteroid than the two normal RV/TLC subgroups. CONCLUSION: COPD subgroups classified by DL(CO) and RV/TLC may have different pulmonary function responses to pharmacological treatment. |
| | |
Authors:
|
J S Lee; J W Huh; E J Chae; J B Seo; S W Ra; J-H Lee; E-K Kim; Y K Lee; T-H Kim; W J Kim; J H Lee; S-M Lee; S Lee; S Y Lim; T R Shin; H I Yoon; S S Sheen; Y-M Oh; S-D Lee |
Related Documents
:
|
7813336 - Pouchitis--a poorly understood entity. 16265776 - Skip inflammation of the appendiceal orifice: a prospective endoscopic study. 17906906 - Preservation of the anal transition zone in ulcerative colitis. long-term effects on de... 20675196 - High intestinal and systemic levels of decoy receptor 3 (dcr3) and its ligand tl1a in a... 17624806 - Late hyperenhancement in gadolinium-enhanced magnetic resonance imaging: comparison of ... 17694766 - Reduced thyrotropin in euthyroid goitrous patients suggesting subclinical hyperthyroidism. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Volume: 15 ISSN: 1815-7920 ISO Abbreviation: Int. J. Tuberc. Lung Dis. Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-07-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9706389 Medline TA: Int J Tuberc Lung Dis Country: France |
Other Details:
|
Languages: eng Pagination: 1104-10 Citation Subset: IM |
Affiliation:
|
Department of Pulmonary and Critical Care Medicine, Asthma Center and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Acute respiratory distress syndrome caused by miliary tuberculosis: a multicentre survey in South Ko...
Next Document: The impact of combined pulmonary fibrosis and emphysema on mortality.