| Different swelling mechanisms in nasal septum (Kiesselbach area) and inferior turbinate responses to histamine: an optical rhinometric study. | |
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MedLine Citation:
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PMID: 16549748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether the inferior turbinate, which contains swelling bodies, and the nasal septum (Kiesselbach area), characterized by a dense arterial mesh, exhibit different swelling mechanisms in allergic nasal reactions. DESIGN: Two optical rhinometers were used to examine 11 patients in the clinic. Optical rhinometry is based on the transillumination of the nasal septum and inferior turbinate or the whole nose with monochromatic light. The instrument's wavelength can be adjusted to the absorption characteristics of reduced hemoglobin, oxygen-saturated hemoglobin, and water. SETTING: Outpatient university otolaryngology clinic. PATIENTS: Eleven young, healthy, nonsmoking, nonpregnant subjects (6 men and 5 women), mean age, 32.4 years (age range, 27-37 years), with no history of exposure to toxic substances, allergies, or other significant diseases. INTERVENTIONS: Optic rhinometry evaluation during the course of nasal histamine administration. MAIN OUTCOME MEASURES: Light extinction at various wavelengths. RESULTS: Following administration of histamine, in the nasal septum, the wavelength of 950 nm (edema) showed the strongest increase of light extinction; in the inferior turbinate, it was the wavelength of 786 nm (oxygenated hemoglobin). In the whole nose, the wavelength of 880 nm (edema plus hemoglobin) exhibited the largest increase of extinction. CONCLUSIONS: Swelling of the nasal septum (Kiesselbach area) in nasal allergic reactions is caused mainly by edema, whereas swelling of the inferior turbinate is due mainly to an increase in volume of blood that is highly saturated with oxygen. Swelling of the whole nose is characterized by the combination of both, edema and increase in blood volume. |
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Authors:
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Eike G Wüstenberg; Mandy Scheibe; Thomas Zahnert; Thomas Hummel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of otolaryngology--head & neck surgery Volume: 132 ISSN: 0886-4470 ISO Abbreviation: Arch. Otolaryngol. Head Neck Surg. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-21 Completed Date: 2006-04-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8603209 Medline TA: Arch Otolaryngol Head Neck Surg Country: United States |
Other Details:
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Languages: eng Pagination: 277-81 Citation Subset: AIM; IM |
Affiliation:
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Hals-Nasen-Ohren-Universitätsklinik, Dresden, Germany. eike.wuestenberg@uniklinikum-dresden.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Edema / pathology Female Histamine / pharmacology* Humans Light / diagnostic use Male Nasal Septum / pathology, physiology* Respiratory Hypersensitivity / physiopathology Turbinates / blood supply, physiology* |
| Chemical | |
Reg. No./Substance:
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51-45-6/Histamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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