Document Detail

Different structural remodelling in atrial fibrillation with different types of mitral valvular diseases.
MedLine Citation:
PMID:  20106797     Owner:  NLM     Status:  MEDLINE    
AIMS: The aim of this study was to determine the relationship between atrial structural remodelling and atrial fibrillation (AF) for different types of mitral valvular diseases (MVDs). METHODS AND RESULTS: Left atrial appendages tissue samples were obtained from 24 patients with MVDs undergoing mitral valve replacement surgery. Masson's trichrome staining and immunohistochemical staining were performed to assess the extent of the fibrosis. Ultrastructural changes in left atrial appendages were examined by electron microscope. The degree of fibrosis showed significant increases in patients with AF compared with patients with sinus rhythm (SR) (P = 0.023). The collagen volume fraction (CVF) of fibrosis significantly increased in mitral stenosis and atrial fibrillation (MS-AF) compared with the mitral regurgitation and atrial fibrillation (MR-AF) group (P = 0.043). Collagen Type I levels were significantly increased in AF patients with mitral stenosis compared with AF patients with mitral regurgitation (P = 0.043). Different CVF of Matrix metalloproteinases-2 was present between the MS-SR group and the MS-AF group (P = 0.001). Electron microscopy revealed normally structured sarcomeres with a predominance of loosely packed cardiomyocytes in samples from patients with SR. Fibrotic bands, which tended to separate individual cardiomyocytes, were apparent in samples from patients with AF. CONCLUSION: Atrial structural remodelling is associated with AF patients with MVDs. Different heart rhythm statuses with different types of MVDs are associated with variable atrial structural remodelling. Different atrial structural remodelling is a mechanism that may contribute to the increased risk of AF with MVDs.
Yongjun Qian; Jun Meng; Hong Tang; Guo Yang; Yiling Deng; Dongming Wei; Bo Xiang; Xijun Xiao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-26
Journal Detail:
Title:  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology     Volume:  12     ISSN:  1532-2092     ISO Abbreviation:  Europace     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883649     Medline TA:  Europace     Country:  England    
Other Details:
Languages:  eng     Pagination:  371-7     Citation Subset:  IM    
Division of Thoracic and Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
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MeSH Terms
Atrial Appendage / metabolism,  pathology*,  ultrastructure
Atrial Fibrillation / epidemiology,  pathology*
Collagen Type I / metabolism
Collagen Type III / metabolism
Matrix Metalloproteinase 2 / metabolism
Matrix Metalloproteinase 9 / metabolism
Microscopy, Electron
Middle Aged
Mitral Valve Stenosis / epidemiology,  pathology*,  surgery
Risk Factors
Staining and Labeling
Tissue Inhibitor of Metalloproteinase-1 / metabolism
Tissue Inhibitor of Metalloproteinase-2 / metabolism
Reg. No./Substance:
0/Collagen Type I; 0/Collagen Type III; 0/Tissue Inhibitor of Metalloproteinase-1; 127497-59-0/Tissue Inhibitor of Metalloproteinase-2; EC Metalloproteinase 2; EC Metalloproteinase 9

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