| Different roles of TiR8/Sigirr on toll-like receptor signaling in intrarenal antigen-presenting cells and tubular epithelial cells. | |
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MedLine Citation:
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PMID: 17495864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Toll-like receptors (TLRs) exist on both myeloid and intrinsic renal cells contributing to the initiation of innate immunity during renal infection with uropathogenic Escherichia coli. Toll-interleukin 1 receptor (IL-1R) (TIR)8/SIGIRR is an orphan receptor of the TLR/IL-1R family, which suppresses TLR signaling of immune cells and is highly expressed in the kidney. Lack of TIR8/SIGIRR is associated with enhanced renal chemokine signaling upon exposure to lipopolysaccharide (LPS). This was because of TIR8/SIGIRR expression on resident intrarenal myeloid cells rather than tubular epithelial cells which express it on basolateral and luminal membranes. The lack of TIR8/SIGIRR does not enhance TLR/IL-1R signaling in tubular epithelial cells as was observed in monocytes. TIR8/SIGIRR is induced in monocytes treated with LPS or tumor necrosis factor and interferon-gamma in a dose-dependent manner but was downregulated in treated tubule epithelial cells. This cell type-specific regulation and function did not relate to mRNA splice variants but was associated with N- and O-glycosylation of the receptor in renal cells of myeloid and nonmyeloid origin. Our studies show that resident myeloid cells contribute to TLR-mediated antimicrobial immunity in the kidney and that this function is controlled by Tir8/sigirr. TIR8/SIGIRR does not suppress TLR signaling in tubular epithelial cells, which supports their role as sensors of microbial infection in the kidney. |
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Authors:
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M Lech; C Garlanda; A Mantovani; C J Kirschning; D Schlöndorff; H-J Anders |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-05-02 |
Journal Detail:
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Title: Kidney international Volume: 72 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-12 Completed Date: 2007-09-21 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
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Languages: eng Pagination: 182-92 Citation Subset: IM |
Affiliation:
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Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigen-Presenting Cells / immunology, metabolism* Cells, Cultured Epithelial Cells / immunology, metabolism* Immunity, Innate Kidney / cytology*, immunology Lipopolysaccharides / pharmacology Mice Mice, Knockout Monocytes Myeloid Cells Receptors, Interleukin-1 / immunology, physiology* Signal Transduction / immunology Toll-Like Receptors / immunology, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Lipopolysaccharides; 0/Receptors, Interleukin-1; 0/Tir8 protein, mouse; 0/Toll-Like Receptors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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