Document Detail

Different results of the Salmonella umu test between three isomers of phenylenediamine (PDA) derivatives.
MedLine Citation:
PMID:  16707328     Owner:  NLM     Status:  MEDLINE    
A post-treatment assay of the umu test was performed to detect genotoxicity of 10 phenylenediamine (PDA) derivatives using Salmonella typhimurium TA1535/pSK1002 with/without S9 mix. Seven chemicals (o-PDA, 4-chloro-o-PDA, 4-nitro-o-PDA, p-PDA, 2-chloro-p-PDA, 2-nitro-p-PDA, and 2,5-diaminotoluene) showed positive results with S9 mix, but three chemicals (m-PDA, 4-chloro-m-PDA, and 2,4-diaminotoluene) were negative with and without S9 mix. Four of 7 chemicals (o-PDA, 4-chloro-o-PDA, 4-nitro-o-PDA, and 2-nitro-p-PDA) that gave positive results with S9 mix were also positive without S9 mix. These results indicate that the genotoxicity of PDA derivative possessing m-position amino substituents was not detected in the umu post-treatment assay using TA1535/pSK1002.
K Yasunaga; A Kiyonari; M Nakagawa; K Yoshikawa
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Drug and chemical toxicology     Volume:  29     ISSN:  0148-0545     ISO Abbreviation:  Drug Chem Toxicol     Publication Date:  2006  
Date Detail:
Created Date:  2006-05-18     Completed Date:  2006-07-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801723     Medline TA:  Drug Chem Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-13     Citation Subset:  IM    
Mitsubishi Chemical Safety Institute Ltd., Ibaraki, Japan.
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MeSH Terms
Dose-Response Relationship, Drug
Mutagenicity Tests*
Mutagens / classification,  toxicity*
Phenylenediamines / chemistry,  classification,  toxicity*
Rats, Sprague-Dawley
Ribosomal Proteins
SOS Response (Genetics) / drug effects*,  genetics
Salmonella / drug effects*,  genetics
Structure-Activity Relationship
Reg. No./Substance:
0/Mutagens; 0/Phenylenediamines; 0/Ribosomal Proteins; 0/ribosomal protein S9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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