Document Detail

Different responses of the isolated canine coronary artery superfused with blood or Krebs-Henseleit solution.
MedLine Citation:
PMID:  6493359     Owner:  NLM     Status:  MEDLINE    
Responses of ring segments of the isolated canine coronary artery superfused with arterial blood from a donor dog were compared with responses of segments superfused with Krebs-Henseleit (K-H) solution. KC1 (1 - 30 mg) caused contraction in a dose-dependent manner both in K-H solution- and in blood-superfused preparation. However, CaCl2 (1 - 100 mg) and nifedipine (0.1 - 30 micrograms) contracted and relaxed, respectively, only blood-superfused preparation but not K-H solution-superfused one. These results show that even in the same region of the coronary artery, different superfusates result in different responses to contracting or relaxing agents. This difference may be explained by the idea that Ca2+-channels are activated and endow basal tension in blood-superfused preparations, but not in K-H solution-superfused ones.
Y Matsumoto; J Inui; K Hashimoto
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  327     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-12-19     Completed Date:  1984-12-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  156-8     Citation Subset:  IM    
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MeSH Terms
Calcium Chloride / pharmacology
Coronary Vessels / drug effects
Muscle Contraction / drug effects
Muscle, Smooth, Vascular / drug effects*
Nifedipine / pharmacology
Potassium / blood
Potassium Chloride / pharmacology
Reg. No./Substance:
0/Solutions; 10043-52-4/Calcium Chloride; 21829-25-4/Nifedipine; 7440-09-7/Potassium; 7447-40-7/Potassium Chloride

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