Document Detail


Different response of oxygen consumption and cardiac output to various endogenous and synthetic catecholamines in awake dogs.
MedLine Citation:
PMID:  11153627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether catecholamines with different adrenergic receptor affinities are characterized by individual relationships between cardiac output (Q) and oxygen consumption (VO2). DESIGN: Comparison of the dose-effect relationships and Q/VO2 relationships of four different catecholamines in the same awake dogs. SETTING: University research department of experimental anesthesiology. SUBJECTS: Ten trained, healthy dogs in the basal metabolic state with chronically implanted ultrasonic flow transducers around the pulmonary artery for the continuous measurement of cardiac output. INTERVENTIONS: Increasing doses of norepinephrine, epinephrine, dobutamine, or dopexamine were infused in a randomly varied sequence on separate days until VO2 and Q reached a maximum. MEASUREMENTS AND MAIN RESULTS: VO2 was measured by indirect calorimetry, and Q was measured via the pulmonary artery by ultrasonic flowmetry. In healthy dogs, catecholamines increased both VO2 and Q in a dose-dependent manner until a plateau was reached when VO2 had doubled and Q had quadrupled compared with baseline conditions. Regardless of the catecholamine, the resulting Q/VO2 relationships were linear up to the maximal effects, but their slopes (s) differed significantly between agents (p < .05, paired sign test) and increased approximately three-fold in the order norepinephrine (s = 34), epinephrine (s = 54), dobutamine (s = 86), and dopexamine (s = 105). Except for norepinephrine, the catecholamines also increased oxygen delivery more than VO2, so that O2 extraction decreased to 40% below baseline. CONCLUSIONS: Catecholamines are characterized by linear Q/VO2 relationships with drug-specific slopes. All agents (except norepinephrine) increased oxygen delivery more than oxygen demand. For the practice of catecholamine therapy, our experiments imply that synthetic agents such as dobutamine and particularly dopexamine may be preferred in the treatment of low cardiac output states because they increase Q with the least metabolic effects.
Authors:
T W Scheeren; J O Arndt
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  28     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-10     Completed Date:  2001-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3861-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Experimental Anesthesiology, Heinrich-Heine University of Düsseldorf, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic Agonists / pharmacology*
Animals
Basal Metabolism
Blood Flow Velocity / drug effects
Calorimetry, Indirect
Cardiac Output / drug effects*
Cardiotonic Agents / pharmacology*
Catecholamines / pharmacology*,  physiology*
Catheterization, Swan-Ganz
Dobutamine / pharmacology*
Dogs
Dopamine / analogs & derivatives*,  pharmacology*,  physiology*
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Epinephrine / pharmacology*,  physiology*
Female
Linear Models
Male
Norepinephrine / pharmacology*,  physiology*
Oxygen Consumption / drug effects*
Random Allocation
Receptors, Adrenergic / drug effects
Rheology
Time Factors
Vasoconstrictor Agents / pharmacology*
Vasodilator Agents / pharmacology*
Wakefulness / physiology
Chemical
Reg. No./Substance:
0/Adrenergic Agonists; 0/Cardiotonic Agents; 0/Catecholamines; 0/Receptors, Adrenergic; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 34368-04-2/Dobutamine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 86197-47-9/dopexamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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