| Different response of liver parenchymal cells from starved and fed rats to cadmium. | |
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MedLine Citation:
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PMID: 6818718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The susceptibility of hepatocytes to the deleterious effects of cadmium (10-100 microM Cd), as evidenced by SH-group content and cell membrane permeability for Trypan Blue (TB), was shown to be strongly dependent on the dietary condition of the donor animal. Although Cd stimulated lipid peroxidation (LPO) equally well in "starved" as in "fed cells", SH-group content and TB-exclusion decreased markedly only in "starved" cells exposed to Cd. Experiments with methionine + serine and/or the antioxidant (+)-cyanidanol-3 suggested that the Cd-dependent LPO proceeded independent of the decrease in SH-group content or TB-exclusion. |
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Authors:
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L Müller; F K Ohnesorge |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: Toxicology Volume: 25 ISSN: 0300-483X ISO Abbreviation: Toxicology Publication Date: 1982 |
Date Detail:
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Created Date: 1983-03-17 Completed Date: 1983-03-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0361055 Medline TA: Toxicology Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 141-50 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cadmium / toxicity* Digitonin / pharmacology Female Glutathione / metabolism Liver / drug effects* Methionine / pharmacology Rats Rats, Inbred Strains Serine / pharmacology Starvation / physiopathology* Sulfhydryl Compounds / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Sulfhydryl Compounds; 11024-24-1/Digitonin; 56-45-1/Serine; 63-68-3/Methionine; 70-18-8/Glutathione; 7440-43-9/Cadmium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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