Document Detail

Different regional brain volume loss in pure and complicated hereditary spastic paraparesis: a voxel-based morphometric study.
MedLine Citation:
PMID:  17852008     Owner:  NLM     Status:  MEDLINE    
Three-dimensional magnetic resonance imaging of the brain was analyzed using optimized voxel-based morphometry in 21 patients with pure hereditary spastic paraparesis (pHSP) and 12 patients with complicated HSP (cHSP). PHSP patients showed only small regional grey matter volume reduction, whereas significantly decreased grey matter volumes were localized pericentrally in cHSP. In the white matter, several small areas of regional volume reduction were observed in the pHSP patients, whereas the cHSP group exhibited large robust volume reduction involving the entire corpus callosum, a result that was reproduced by an additional region-based MRI analysis. It could be demonstrated that the topography of cerebral volume changes differed markedly in pHSP or cHSP at group level. Corpus callosum thinning seems to be a general feature of cHSP.
Jan Kassubek; Freimut D Juengling; Annette Baumgartner; Alexander Unrath; Albert C Ludolph; Anne-D Sperfeld
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-30
Journal Detail:
Title:  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases     Volume:  8     ISSN:  1471-180X     ISO Abbreviation:  Amyotroph Lateral Scler     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-09-16     Completed Date:  2009-03-16     Revised Date:  2009-11-17    
Medline Journal Info:
Nlm Unique ID:  101283386     Medline TA:  Amyotroph Lateral Scler     Country:  England    
Other Details:
Languages:  eng     Pagination:  328-36     Citation Subset:  IM    
Department of Neurology, University of Ulm, Germany.
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MeSH Terms
Atrophy / pathology
Brain / pathology*,  physiology
Brain Mapping / methods
Image Interpretation, Computer-Assisted / methods*
Imaging, Three-Dimensional / methods
Magnetic Resonance Imaging / methods*
Middle Aged
Organ Size / physiology
Paraparesis, Spastic / genetics*,  pathology*

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