| Different plasma levels of nitric oxide in arterial and venous blood. | |
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MedLine Citation:
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PMID: 10516896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experimental investigations suggest that a basal release of nitric oxide (NO) occurs in arterial but not in venous endothelium. We therefore decided to compare plasma levels of NO in the arterial and venous circulation. Parallel blood samples were drawn from the radial artery and brachial vein in 15 healthy drug-free women. Nitric oxide levels were assessed by measuring plasma levels of nitrite and nitrate, the two stable oxidation products of NO metabolism. Plasma levels of NO metabolites in arterial blood were significantly higher than in the paired venous blood samples (45.1 +/- 17.7 versus 22.5 +/- 8.5 mumol l-1, respectively, mean +/- SD). The results of this preliminary study strongly suggest that the endothelial release of NO is probably different in arteries and veins in vivo; this is also consistent with previous literature indicating that basal release of NO occurs mainly from the endothelium of arteries but not from that of veins. |
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Authors:
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E Cicinelli; L J Ignarro; L M Schonauer; M G Matteo; P Galantino; N Falco |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical physiology (Oxford, England) Volume: 19 ISSN: 0144-5979 ISO Abbreviation: Clin Physiol Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-10-28 Completed Date: 1999-10-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8309768 Medline TA: Clin Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 440-2 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Bari, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arteries
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physiology Biological Markers / blood Endothelium, Vascular / metabolism Female Humans Middle Aged Nitric Oxide / blood* Postmenopause / blood Veins / physiology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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