Document Detail

Different plasma levels of nitric oxide in arterial and venous blood.
MedLine Citation:
PMID:  10516896     Owner:  NLM     Status:  MEDLINE    
Experimental investigations suggest that a basal release of nitric oxide (NO) occurs in arterial but not in venous endothelium. We therefore decided to compare plasma levels of NO in the arterial and venous circulation. Parallel blood samples were drawn from the radial artery and brachial vein in 15 healthy drug-free women. Nitric oxide levels were assessed by measuring plasma levels of nitrite and nitrate, the two stable oxidation products of NO metabolism. Plasma levels of NO metabolites in arterial blood were significantly higher than in the paired venous blood samples (45.1 +/- 17.7 versus 22.5 +/- 8.5 mumol l-1, respectively, mean +/- SD). The results of this preliminary study strongly suggest that the endothelial release of NO is probably different in arteries and veins in vivo; this is also consistent with previous literature indicating that basal release of NO occurs mainly from the endothelium of arteries but not from that of veins.
E Cicinelli; L J Ignarro; L M Schonauer; M G Matteo; P Galantino; N Falco
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical physiology (Oxford, England)     Volume:  19     ISSN:  0144-5979     ISO Abbreviation:  Clin Physiol     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-28     Completed Date:  1999-10-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8309768     Medline TA:  Clin Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  440-2     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Bari, Italy.
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MeSH Terms
Arteries / physiology
Biological Markers / blood
Endothelium, Vascular / metabolism
Middle Aged
Nitric Oxide / blood*
Postmenopause / blood
Veins / physiology
Reg. No./Substance:
0/Biological Markers; 10102-43-9/Nitric Oxide

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