Document Detail

Different peripheral vasodilator effects of isradipine in sodium-loaded and sodium-depleted rabbits.
MedLine Citation:
PMID:  2965053     Owner:  NLM     Status:  MEDLINE    
1. The influence of acute changes in salt balance on the cardiovascular effects of the calcium antagonist isradipine were investigated in two groups of 6 rabbits pretreated 24 hr before an acute experiment, one by substituting 0.45% NaCl for drinking water, the other one with a subcutaneous injection of 20 mg kg-1 furosemide. 2. On the next day the animals were anaesthetized with barbiturates and 10 ml kg-1 0.9% NaCl or 5% glucose were infused into the salt loaded and salt depleted animals respectively. 3. Regional blood flows were then measured with microspheres before and after i.v. administration of 3 and 10 micrograms kg-1 isradipine (PN200-110). 4. Salt depleted animals had a lower cardiac output and lower flows to several regional vascular beds including the kidneys. 5. The isradipine effects on systemic haemodynamic variables were not different in the two groups. 6. However, the effects on regional blood flows were modified. In salt loaded animals skeletal muscle flow increased more, starting from a higher baseline, yet flow to the kidneys, pancrease and spleen was higher before and decreased significantly more after the calcium antagonist. 7. The results suggest that an alteration in the sodium balance selectively affects the mechanism responsible for vascular tone in a few vascular beds.
R P Hof; A Hof-Miyashita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  General pharmacology     Volume:  19     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1988  
Date Detail:
Created Date:  1988-05-12     Completed Date:  1988-05-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  243-7     Citation Subset:  IM    
Cardiovascular Unit of Preclinical Research, Sandoz Ltd., Basel, Switzerland.
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MeSH Terms
Calcium Channel Blockers / pharmacology*
Hemodynamics / drug effects
Pyridines / pharmacology*
Regional Blood Flow / drug effects
Sodium / pharmacology*,  physiology
Vasodilator Agents*
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Pyridines; 0/Vasodilator Agents; 7440-23-5/Sodium; 75695-93-1/Isradipine

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