Document Detail

Different patterns of pulse spectrum between survivors and non-survivors during progressive hemorrhage in rats.
MedLine Citation:
PMID:  16883629     Owner:  NLM     Status:  MEDLINE    
Previous work from our laboratory has demonstrated that the percentage differences of 2nd (C2) and 3rd (C3) pulse harmonics related to Kidney and Spleen were both increased toward another steady state in rats after acute hemorrhage. Therefore, it is suggested that changes in pulse spectra might represent the ability of animals to survive a model of progressive hemorrhage. In this study, the difference of the pulse spectra patterns between survivors and non-survivors after progressive hemorrhage (by loss of 5%, 10% or 20% of the estimated blood volume) in anesthetized rats is determined. Seven rats, dead within 2 hours after a loss of 20% of the estimated blood volume hemorrhage, were defined as 'non-survivors'. The other eleven rats, more than 2 hours after hemorrhage, were defined as 'survivors'. Pulse waves of arterial blood pressure before and after the hemorrhage were measured in parallel to the pulse spectrum analysis. Data among different phases were analyzed using one-way analysis of variance (ANOVA) with Duncan's test for pairwise comparisons. Differences between survivor and non-survivor groups at each phase were analyzed using Student's t-test. A mixed-effects linear regression model was applied to evaluate the relationship in harmonics, which significantly differed between the two groups. The study results showed that in rats, during progressive hemorrhage, the percentage differences of 2nd harmonic proportion increased significantly; however, the result failed to show any significant difference between survivors and non-survivors. After the third blood withdrawal process, the percentage differences of 3rd harmonic proportion increased more significantly in the survivors. In addition, the percentage differences of 1st harmonic proportion related to the Liver for the survivor group was significantly lower than that of the non-survivors. After analysis with the mixed linear regression model, C3 and C1 demonstrated a linear regression relationship, and there existed significant differences between survivors and non-survivors. These results suggest that C3 might play an important role in physiology regarding surviving capability after progressive hemorrhage.
Yu Hsin Chang; Jui Shan Lin; Jaung Geng Lin; Yue Der Lin; Tsai Chung Li; Yi Chang Su
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of Chinese medicine     Volume:  34     ISSN:  0192-415X     ISO Abbreviation:  Am. J. Chin. Med.     Publication Date:  2006  
Date Detail:
Created Date:  2006-08-02     Completed Date:  2006-10-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7901431     Medline TA:  Am J Chin Med     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  575-89     Citation Subset:  IM    
Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan, ROC.
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MeSH Terms
Analysis of Variance
Blood Pressure / physiology
Hemorrhage / mortality,  physiopathology*
Pulsatile Flow / physiology
Rats, Sprague-Dawley
Survival Rate
Time Factors

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