Document Detail


Different patterns of inhibition of adrenaline-induced platelet aggregation and kinetics in vivo by acetylsalicylic acid and indobufen.
MedLine Citation:
PMID:  1916004     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The inhibitory effect of 50 mg/kg lysyl acetylsalicylic acid (ASA) intravenously injected 24 and 4 h before 80 micrograms/kg adrenaline, 40 mg/kg indobufen injected 15 min before, or a combination of ASA plus indobufen on the platelet aggregation and kinetics was evaluated in anaesthetized dogs previously injected with 111indium- (111In-) labelled platelets using gamma-camera dynamics studies. The highest degree of inhibition, indicated by the lowest platelet aggregation ratio decrease and the most significant 111In-labelled platelet mobilization from hepatic and splenic stores with a corresponding increase of labelled and unlabelled platelet counts in blood, was obtained in ASA-treated dogs. Such changes were less marked when ASA plus indobufen was injected. In indobufen-treated dogs a similar mobilization of 111In-labelled platelets with an increase in circulating platelet numbers was evident only after the second adrenaline injection. It is concluded that platelet mobilization is mainly dependent on the production of an ASA-sensitive substance.
Authors:
J S Fortunato; M J Pinheiro; M C Monteiro; M A Rodrigues; I Amaral
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of international medical research     Volume:  19     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    1991 Jul-Aug
Date Detail:
Created Date:  1991-11-08     Completed Date:  1991-11-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  305-17     Citation Subset:  IM    
Affiliation:
Physiological Haemostasis Centre, Oporto Medical School, Portugal.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aspirin / pharmacology*
Blood Platelets / drug effects
Dogs
Epinephrine / antagonists & inhibitors,  pharmacology*
Injections, Intravenous
Isoindoles
Kinetics
Liver / drug effects
Male
Phenylbutyrates / pharmacology*
Platelet Aggregation / drug effects*
Platelet Aggregation Inhibitors / pharmacology*
Platelet Count / drug effects
Propranolol / pharmacology
Spleen / drug effects
Chemical
Reg. No./Substance:
0/Isoindoles; 0/Phenylbutyrates; 0/Platelet Aggregation Inhibitors; 36690-96-7/indobufen; 50-78-2/Aspirin; 51-43-4/Epinephrine; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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