Document Detail


Different orientation tuning of near- and far-surround suppression in macaque primary visual cortex mirrors their tuning in human perception.
MedLine Citation:
PMID:  23283326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In primary visual cortex (V1), neuronal responses to stimuli inside the receptive field (RF) are usually suppressed by stimuli in the RF surround. This suppression is orientation specific. Similarly, in human vision surround stimuli can suppress perceived contrast of a central stimulus in an orientation-dependent manner. The surround consists of two regions likely generated by different circuits: a near-surround generated predominantly by geniculocortical and intra-V1 horizontal connections, and a far-surround generated exclusively by interareal feedback. Using stimuli confined to the near- or far-surround of V1 neurons, and similar stimuli in human psychophysics, we find that near-surround suppression is more sharply orientation tuned than far-surround suppression in both macaque V1 and human perception. These results point to a similarity between surround suppression in macaque V1 and human vision, and suggest that feedback circuits are less orientation biased than horizontal circuits. We find the sharpest tuning of near-surround suppression in V1 layers (3, 4B, 4Cα) with patterned and orientation-specific horizontal connections. Sharpest tuning of far-surround suppression occurs in layer 4B, suggesting greater orientation specificity of feedback to this layer. Different orientation tuning of near- and far-surround suppression may reflect a statistical bias in natural images, whereby nearby edges have higher probability than distant edges of being co-oriented and belonging to the same contour. Surround suppression would, thus, increase the coding efficiency of frequently co-occurring contours and the saliency of less frequent ones. Such saliency increase can help detect small orientation differences in nearby edges (for contour completion), but large orientation differences in distant edges (for directing saccades/attention).
Authors:
S Shushruth; Lauri Nurminen; Maryam Bijanzadeh; Jennifer M Ichida; Simo Vanni; Alessandra Angelucci
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  33     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-03     Completed Date:  2013-03-12     Revised Date:  2013-07-18    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  106-19     Citation Subset:  IM    
Affiliation:
Neuroscience Program, University of Utah, Salt Lake City, Utah 84132, USA.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology*
Animals
Female
Humans
Macaca fascicularis
Male
Neurons / physiology*
Orientation / physiology*
Photic Stimulation
Visual Cortex / physiology*
Visual Fields / physiology
Visual Pathways / physiology
Visual Perception / physiology*
Grant Support
ID/Acronym/Agency:
EY015262/EY/NEI NIH HHS; P30 EY014800/EY/NEI NIH HHS; R01 EY015262/EY/NEI NIH HHS; R01 EY019743/EY/NEI NIH HHS
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