Document Detail


Different mutational pathways to CXCR4 coreceptor switch of CCR5-using simian-human immunodeficiency virus.
MedLine Citation:
PMID:  18385246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report here a second case of coreceptor switch in R5 simian-human immunodeficiency virus SF162P3N (SHIV(SF162P3N))-infected macaque CA28, supporting the use of this experimental system to examine factors that drive the change in coreceptor preference in vivo. Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively. Sequence and functional analyses showed that mutations in the V3 loop that conferred CXCR4 usage in macaque CA28 differed from those described in the previously reported case, demonstrating divergent mutational pathways for change in the coreceptor preference of the R5 SHIV(SF162P3N) isolate in vivo.
Authors:
Siu-hong Ho; Nataliya Trunova; Agegnehu Gettie; James Blanchard; Cecilia Cheng-Mayer
Related Documents :
16103166 - Differential pathogenesis of primary ccr5-using human immunodeficiency virus type 1 iso...
21949746 - Distinguishing characteristics between pandemic 2009-2010 influenza a (h1n1) and other ...
16298986 - Evolution of human immunodeficiency virus type 2 coreceptor usage, autologous neutraliz...
15367626 - Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infec...
12829856 - Differential hyperacetylation of histones h3 and h4 upon promoter-specific recruitment ...
24322446 - A negative effect of a pathogen on its vector? a plant pathogen increases the vulnerabi...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-04-02
Journal Detail:
Title:  Journal of virology     Volume:  82     ISSN:  1098-5514     ISO Abbreviation:  J. Virol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-15     Completed Date:  2008-06-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5653-6     Citation Subset:  IM    
Affiliation:
Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave., 7th Floor, New York, NY 10016, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/EU564103;  EU564104
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
CD4-Positive T-Lymphocytes / cytology,  metabolism
Lymphocyte Count
Macaca mulatta / genetics,  metabolism,  virology
Molecular Sequence Data
Mutation / genetics
Receptors, CCR5 / metabolism*
Receptors, CXCR4 / metabolism*
Simian immunodeficiency virus / chemistry,  genetics*,  metabolism*
Viral Proteins / chemistry,  genetics,  metabolism
Grant Support
ID/Acronym/Agency:
R01 AI46980/AI/NIAID NIH HHS; R37AI41945/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, CCR5; 0/Receptors, CXCR4; 0/Viral Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Transformation by bovine papillomavirus type 1 E6 requires paxillin.
Next Document:  Insertion of the two cleavage sites of the respiratory syncytial virus fusion protein in Sendai viru...