Document Detail

Different mutational pathways to CXCR4 coreceptor switch of CCR5-using simian-human immunodeficiency virus.
MedLine Citation:
PMID:  18385246     Owner:  NLM     Status:  MEDLINE    
We report here a second case of coreceptor switch in R5 simian-human immunodeficiency virus SF162P3N (SHIV(SF162P3N))-infected macaque CA28, supporting the use of this experimental system to examine factors that drive the change in coreceptor preference in vivo. Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively. Sequence and functional analyses showed that mutations in the V3 loop that conferred CXCR4 usage in macaque CA28 differed from those described in the previously reported case, demonstrating divergent mutational pathways for change in the coreceptor preference of the R5 SHIV(SF162P3N) isolate in vivo.
Siu-hong Ho; Nataliya Trunova; Agegnehu Gettie; James Blanchard; Cecilia Cheng-Mayer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-04-02
Journal Detail:
Title:  Journal of virology     Volume:  82     ISSN:  1098-5514     ISO Abbreviation:  J. Virol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-15     Completed Date:  2008-06-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5653-6     Citation Subset:  IM    
Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave., 7th Floor, New York, NY 10016, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/EU564103;  EU564104
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MeSH Terms
Amino Acid Sequence
CD4-Positive T-Lymphocytes / cytology,  metabolism
Lymphocyte Count
Macaca mulatta / genetics,  metabolism,  virology
Molecular Sequence Data
Mutation / genetics
Receptors, CCR5 / metabolism*
Receptors, CXCR4 / metabolism*
Simian immunodeficiency virus / chemistry,  genetics*,  metabolism*
Viral Proteins / chemistry,  genetics,  metabolism
Grant Support
Reg. No./Substance:
0/Receptors, CCR5; 0/Receptors, CXCR4; 0/Viral Proteins

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