| Different modes of sensory neuropeptides and nitric oxide involvement in relaxation of guinea-pig vessels. | |
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MedLine Citation:
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PMID: 8690844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigated involvement of calcitonin-gene-related peptide (CGRP), substance P (SP) and nitric oxide (NO) in transmural nerve stimulation (TNS)-induced non-adrenergic, non-cholinergic (NANC) relaxation in isolated guinea pig anterior mesenteric artery (AMA) and posterior caval vein (PCV). Effects of cyclo-oxygenase-generated eicosanoids were blocked with indomethacin (10(-5) M) and so were adrenergic and cholinergic responses with phentolamine (3 x 10(-6) M), propranolol (10(-6) M) and atropine (10(-6) M). In both vessels precontracted by U-46619, TNS induced relaxation, which was almost completely abolished by capsaicin pretreatment (10(-6) M, 15 minutes). In AMA, a CGRP1 receptor antagonist (human CGRP8-37, 10(-5) M) significantly attenuated the relaxation, while did both human CGRP8-37 (10(-5) M) and neurokinin-1 receptor antagonists (spantide, 2 x 10(-5) M and FK888, 3 x 10(-6) M) in PCV. NG-nitro-L-arginine methyl ester (10(-4) M) did not significantly attenuate either the NANC-or CGRP-induced relaxation in AMA. However, it significantly did attenuate both the NANC-and SP-induced relaxation, and it also considerably attenuated CGRP-induced relaxation although insignificantly, in PCV. Thus, CGRP could be significantly responsible for the NO-independent NANC relaxation in AMA, whereas both CGRP and SP could additionally relax PCV in a NO-dependent manner. |
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Authors:
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H Matsuda; F Ohmori; M Uematsu; S Nagata; K Miyatake |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the autonomic nervous system Volume: 55 ISSN: 0165-1838 ISO Abbreviation: J. Auton. Nerv. Syst. Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1996-08-26 Completed Date: 1996-08-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8003419 Medline TA: J Auton Nerv Syst Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 115-22 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Osaka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Animals Arginine / analogs & derivatives, pharmacology Calcitonin Gene-Related Peptide / pharmacology Capsaicin / pharmacology Dipeptides / pharmacology Dose-Response Relationship, Drug Electric Stimulation Female Guinea Pigs Indoles / pharmacology Male Muscle Relaxation / drug effects, physiology* Muscle, Smooth, Vascular / innervation, physiology* NG-Nitroarginine Methyl Ester Neurons, Afferent / drug effects, physiology* Neuropeptides / physiology* Nitric Oxide / antagonists & inhibitors, physiology* Prostaglandin Endoperoxides, Synthetic / pharmacology Receptors, Neurotransmitter / antagonists & inhibitors Substance P / analogs & derivatives, pharmacology Thromboxane A2 / analogs & derivatives, pharmacology Vasoconstrictor Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Dipeptides; 0/Indoles; 0/Neuropeptides; 0/Prostaglandin Endoperoxides, Synthetic; 0/Receptors, Neurotransmitter; 0/Vasoconstrictor Agents; 10102-43-9/Nitric Oxide; 138449-07-7/FK 888; 33507-63-0/Substance P; 404-86-4/Capsaicin; 50903-99-6/NG-Nitroarginine Methyl Ester; 57576-52-0/Thromboxane A2; 74-79-3/Arginine; 76898-47-0/15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 83652-28-2/Calcitonin Gene-Related Peptide; 91224-37-2/spantide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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