Document Detail

Different models in predicting the short-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure.
MedLine Citation:
PMID:  22481448     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: Effective assessing the prognosis of patients with end-stage liver disease is always challenging. This study aimed to investigate the accuracy of different models in predicting short-term prognosis of patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF).
MATERIAL AND METHODS: We retrospectively evaluated survival of a cohort of patients with at least 3-month follow up. The receiver-operating-characteristic curves (ROC) were drawn for Child-Turcotte-Pugh (CTP) classification, King's College Hospital (KCH) criteria, model for end-stage liver disease (MELD), MELD combined with serum sodium (Na) concentration (MELDNa), integrated MELD (iMELD) and logistic regression model (LRM).
RESULTS: Of the 273 eligible patients, 152 patients (55.7%) died within 3-month follow up. In cirrhotic patients (n = 101), the AUCs of LRM (0.851), MELDNa (0.849), iMELD (0.845) and MELD (0.840) were all significantly higher than those of KCH criteria (0.642) and CTP (0.625) (all p < 0.05), while the differences among LRM, MELD, MELDNa and iMELD were not significant, and the most predictive cutoff value was 0.5176 for LRM, 30 for MELDNa, 47.87 for iMELD and 29 for MELD, respectively. In non-cirrhotic patients (n = 172), the AUC of LRM (0.897) was significantly higher than that of MELDNa (0.776), iMELD (0.768), MELD (0.758), KCH criteria (0.647) and CTP (0.629), respectively (all p < 0.05), and the most predictive cutoff value for LRM was -0.3264.
CONCLUSIONS: LRM, MELD, MELDNa and iMELD are with similar accuracy in predicting the shortterm prognosis of HBV-ACLF patients with liver cirrhosis, while LRM is superior to MELD, MELDNa and iMELD in predicting the short-term prognosis of HBV-ACLF patients without liver cirrhosis.
Wen-Bin Yang; En-Qiang Chen; Hong-Xia Bi; Lang Bai; Xue-Bin Chen; Ping Feng; Hong Tang
Related Documents :
22248198 - Protein oxidative stress and dyslipidemia in dialysis patients.
21822748 - Ongoing abdominal status myoclonus in postanoxic coma.
22242628 - Unusually high association of hypertrophic cardiomyopathy and complex heart defects in ...
22211098 - P-wave dispersion for predicting paroxysmal atrial fibrillation in acute ischemic stroke.
24597828 - Relevance of novel inflammatory markers in stroke-induced immunosuppression.
23430548 - Subjective and objective assessment of hand function in mucopolysaccharidosis iva patie...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of hepatology     Volume:  11     ISSN:  1665-2681     ISO Abbreviation:  Ann Hepatol     Publication Date:    2012 May-Jun
Date Detail:
Created Date:  2012-04-06     Completed Date:  2012-08-23     Revised Date:  2013-05-16    
Medline Journal Info:
Nlm Unique ID:  101155885     Medline TA:  Ann Hepatol     Country:  Mexico    
Other Details:
Languages:  eng     Pagination:  311-9     Citation Subset:  IM    
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cohort Studies
End Stage Liver Disease / diagnosis*,  virology*
Follow-Up Studies
Hepatitis B / complications
Hepatitis B virus*
Liver Failure, Acute / diagnosis*,  virology*
Logistic Models*
Middle Aged
ROC Curve
Regression Analysis
Retrospective Studies
Sodium / blood
Young Adult
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Acute kidney injury in critically ill cirrhotic patients: a review.
Next Document:  Is there an association between the measurement of qualitative HBsAg and virologic response in chro...