| Different models in predicting the short-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure. | |
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MedLine Citation:
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PMID: 22481448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: Effective assessing the prognosis of patients with end-stage liver disease is always challenging. This study aimed to investigate the accuracy of different models in predicting short-term prognosis of patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF). MATERIAL AND METHODS: We retrospectively evaluated survival of a cohort of patients with at least 3-month follow up. The receiver-operating-characteristic curves (ROC) were drawn for Child-Turcotte-Pugh (CTP) classification, King's College Hospital (KCH) criteria, model for end-stage liver disease (MELD), MELD combined with serum sodium (Na) concentration (MELDNa), integrated MELD (iMELD) and logistic regression model (LRM). RESULTS: Of the 273 eligible patients, 152 patients (55.7%) died within 3-month follow up. In cirrhotic patients (n = 101), the AUCs of LRM (0.851), MELDNa (0.849), iMELD (0.845) and MELD (0.840) were all significantly higher than those of KCH criteria (0.642) and CTP (0.625) (all p < 0.05), while the differences among LRM, MELD, MELDNa and iMELD were not significant, and the most predictive cutoff value was 0.5176 for LRM, 30 for MELDNa, 47.87 for iMELD and 29 for MELD, respectively. In non-cirrhotic patients (n = 172), the AUC of LRM (0.897) was significantly higher than that of MELDNa (0.776), iMELD (0.768), MELD (0.758), KCH criteria (0.647) and CTP (0.629), respectively (all p < 0.05), and the most predictive cutoff value for LRM was -0.3264. CONCLUSIONS: LRM, MELD, MELDNa and iMELD are with similar accuracy in predicting the shortterm prognosis of HBV-ACLF patients with liver cirrhosis, while LRM is superior to MELD, MELDNa and iMELD in predicting the short-term prognosis of HBV-ACLF patients without liver cirrhosis. |
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Authors:
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Wen-Bin Yang; En-Qiang Chen; Hong-Xia Bi; Lang Bai; Xue-Bin Chen; Ping Feng; Hong Tang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of hepatology Volume: 11 ISSN: 1665-2681 ISO Abbreviation: Ann Hepatol Publication Date: 2012 May-Jun |
Date Detail:
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Created Date: 2012-04-06 Completed Date: 2012-08-23 Revised Date: 2013-05-16 |
Medline Journal Info:
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Nlm Unique ID: 101155885 Medline TA: Ann Hepatol Country: Mexico |
Other Details:
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Languages: eng Pagination: 311-9 Citation Subset: IM |
Affiliation:
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Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Cohort Studies End Stage Liver Disease / diagnosis*, virology* Female Follow-Up Studies Hepatitis B / complications Hepatitis B virus* Humans Liver Failure, Acute / diagnosis*, virology* Logistic Models* Male Middle Aged Prognosis ROC Curve Regression Analysis Retrospective Studies Sodium / blood Young Adult |
| Chemical | |
Reg. No./Substance:
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7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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