Document Detail

Different mode of action of endothelin-1 in parietal and visceral veins.
MedLine Citation:
PMID:  8223896     Owner:  NLM     Status:  MEDLINE    
The mode of contractile effect of endothelin-1 in venous smooth muscles was evaluated using three isolated veins, the jugular vein, the portal vein and the inferior caval vein of dogs. The contractile responses to endothelin-1 were attenuated by atropine and augmented by neostigmine in the inferior caval and portal veins, but were not affected by either agent in the jugular vein. We conclude that the contractile responses of visceral veins to endothelin-1 are partly mediated via endogenously released acetylcholine.
A Hayakawa; M Kawanishi; N Ishikawa; Y Shimada; K Goto
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  239     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-12-01     Completed Date:  1993-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  219-22     Citation Subset:  IM    
Department of Anesthesiology, Nagoya University School of Medicine, Japan.
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MeSH Terms
Atropine / pharmacology
Dose-Response Relationship, Drug
Endothelins / pharmacology*
Jugular Veins / drug effects*,  physiology
Muscle Contraction / drug effects
Muscle, Smooth, Vascular / drug effects*,  physiology
Neostigmine / pharmacology
Portal Vein / drug effects*,  physiology
Vena Cava, Inferior / drug effects*,  physiology
Reg. No./Substance:
0/Endothelins; 51-55-8/Atropine; 59-99-4/Neostigmine

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