| Different mode of action of endothelin-1 in parietal and visceral veins. | |
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MedLine Citation:
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PMID: 8223896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mode of contractile effect of endothelin-1 in venous smooth muscles was evaluated using three isolated veins, the jugular vein, the portal vein and the inferior caval vein of dogs. The contractile responses to endothelin-1 were attenuated by atropine and augmented by neostigmine in the inferior caval and portal veins, but were not affected by either agent in the jugular vein. We conclude that the contractile responses of visceral veins to endothelin-1 are partly mediated via endogenously released acetylcholine. |
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Authors:
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A Hayakawa; M Kawanishi; N Ishikawa; Y Shimada; K Goto |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 239 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1993 Aug |
Date Detail:
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Created Date: 1993-12-01 Completed Date: 1993-12-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 219-22 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Nagoya University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atropine / pharmacology Dogs Dose-Response Relationship, Drug Endothelins / pharmacology* Jugular Veins / drug effects*, physiology Muscle Contraction / drug effects Muscle, Smooth, Vascular / drug effects*, physiology Neostigmine / pharmacology Portal Vein / drug effects*, physiology Vena Cava, Inferior / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Endothelins; 51-55-8/Atropine; 59-99-4/Neostigmine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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