Document Detail


Different microcirculatory and interstitial matrix patterns in idiopathic dilated cardiomyopathy and Chagas' disease: a three dimensional confocal microscopy study.
MedLine Citation:
PMID:  10455076     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To analyse the morphological aspects of the extracellular matrix and microcirculation to clarify whether chronic Chagas' cardiopathy (CCC) is an accurate model to study the pathogenesis of idiopathic dilated cardiomyopathy (IDCM). DESIGN: Thick histological myocardial sections were prepared to analyse collagen, and microcirculation was examined during confocal laser and light microscopy. SETTING: The specimens were prepared at the pathology service of the Heart Institute of São Paulo, Brazil. PATIENTS: Nine control hearts, eight IDCM hearts, and 10 CCC hearts were studied after necropsy. MAIN OUTCOME MEASURES: The number of collagen struts per 100x field, the area of fibrosis (%), and the diameters of arterioles and capillaries were measured in each heart to establish outcome. RESULTS: A smaller number (mean (SD)) of collagen struts was seen in the hearts in the IDCM group (9.1 (4.1)) than in the control (22.4 (3.2)) (p < 0.05) or CCC (15.7 (7.4)) (p > 0.05) groups. Fibrosis was greater in the CCC hearts (13.8 (10.5)%) than in the IDCM hearts (5.9 (6.6)%) (p > 0.05). Major increases in arteriole (65.4 (9.9) microm) and capillary (9.9 (1.7) microm) diameters were seen in the CCC hearts but not in the IDCM hearts (arteriole diameter 40.3 (7.9) microm; capillary diameter 7.9 (1.3) microm). CONCLUSIONS: Hearts demonstrating CCC and IDCM present different extracellular and microvessel alterations. This suggests that distinct pathogenic mechanisms are responsible for each condition and that CCC is not an effective model to study IDCM.
Authors:
M L Higuchi; S Fukasawa; T De Brito; L C Parzianello; G Bellotti; J A Ramires
Related Documents :
21245636 - Absence of left atrium-coronary sinus musculature electrical connection at coronary sin...
20735616 - The outflow tract of the heart in fishes: anatomy, genes and evolution.
20235196 - How does the tubular embryonic heart work? looking for the physical mechanism generatin...
17733436 - Measurement of human heart rate during usual activty.
11323586 - Self-expanding metal esophageal stent with anti-reflux mechanism.
23615576 - Hbi-3000 prevents secondary sudden cardiac death.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  82     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-07     Completed Date:  1999-10-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  279-85     Citation Subset:  AIM; IM    
Affiliation:
Service of Pathology, Heart Institute of São Paulo University Medical School, Av Dr Eneas C Aguiar, 44-São Paulo, CEP 05403/000, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Arterioles / pathology
Capillaries / pathology
Cardiomyopathy, Dilated / metabolism,  pathology*
Chagas Cardiomyopathy / metabolism,  pathology*
Child
Collagen / analysis
Coronary Vessels / pathology*
Extracellular Matrix / pathology
Female
Humans
Male
Microscopy, Confocal
Middle Aged
Chemical
Reg. No./Substance:
9007-34-5/Collagen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cardiac M(2) muscarinic cholinoceptor activation by human chagasic autoantibodies: association with ...
Next Document:  Cystic medial degeneration of the aorta is associated with p53 accumulation, Bax upregulation, apopt...