Document Detail


Different melatonin rhythms and sleep-wake rhythms in patients on peritoneal dialysis, daytime hemodialysis and nocturnal hemodialysis.
MedLine Citation:
PMID:  19596605     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Little comparative data on sleep-wake rhythms in different dialysis groups exist. The aim of this study was to investigate sleep-wake parameters measured with actigraphy and sleep questionnaires as well as melatonin rhythms in automated peritoneal dialysis, conventional daytime hemodialysis and nocturnal hemodialysis patients. METHODS: Conventional daytime dialysis (n=20), nocturnal hemodialysis (n=13) and automated peritoneal dialysis patients (n=6) were included in the study. Melatonin in saliva was sampled at 5 time points (21:00, 23:00, 1:00, 7:00 and 9:00 h). Furthermore, actigraphy measurements and sleep questionnaires were performed. All parameters were tested by Kruskall-Wallis test (followed by post hoc Dunn test) to find significant differences (p<0.05). RESULTS: Although most sleep parameters were impaired in all three groups, conventional daytime dialysis patients had the worst sleep. In nocturnal hemodialysis patients a normal nocturnal melatonin rise was found. In daytime hemodialysis and automated peritoneal dialysis patients this rise was absent. CONCLUSIONS: The study showed impaired sleep parameters in all dialysis patient groups. As automated peritoneal dialysis is also performed during night time, the same effect on normalized melatonin was anticipated as was found in nocturnal hemodialysis. Melatonin seems to play a subordinate role in the sleep-wake rhythm of automated peritoneal dialysis patients.
Authors:
Birgit C P Koch; J Elsbeth Nagtegaal; E Christiaan Hagen; Pieter M ter Wee; Gerard A Kerkhof
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-10
Journal Detail:
Title:  Sleep medicine     Volume:  11     ISSN:  1878-5506     ISO Abbreviation:  Sleep Med.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100898759     Medline TA:  Sleep Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  242-6     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier B.V. All rights reserved.
Affiliation:
Department of Clinical Pharmacy, Meander Medical Center, ES Amersfoort, The Netherlands. BCP.Koch@meandermc.nl
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MeSH Terms
Descriptor/Qualifier:
Actigraphy
Aged
Circadian Rhythm / physiology*
Female
Humans
Kidney Failure, Chronic / physiopathology,  therapy
Male
Melatonin / analysis,  physiology*
Middle Aged
Peritoneal Dialysis / adverse effects*
Questionnaires
Renal Dialysis / adverse effects*
Saliva / chemistry
Sleep Disorders / etiology
Statistics, Nonparametric
Time Factors
Chemical
Reg. No./Substance:
73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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