Document Detail

Different means, same end-heterochromatin formation by RNAi and RNAi-independent RNA processing factors in fission yeast.
MedLine Citation:
PMID:  22243696     Owner:  NLM     Status:  MEDLINE    
The assembly of heterochromatin in eukaryotic genomes is critical for diverse chromosomal events including regulation of gene expression, silencing of repetitive DNA elements, proper segregation of chromosomes and maintenance of genomic integrity. Previous studies have shown that noncoding RNAs and the RNA interference (RNAi) machinery promote the assembly of heterochromatin that serves as a multipurpose platform for targeting effectors involved in various chromosomal processes. Recent work has revealed that RNAi-independent mechanisms, involving RNA processing activities that utilize both noncoding and coding RNAs, operate in the assembly of heterochromatin. These findings have established that, in addition to coding for proteins, mRNAs also function as signaling molecules that modify chromatin structure by targeting heterochromatin assembly factors.
Francisca E Reyes-Turcu; Shiv Is Grewal
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review     Date:  2012-01-11
Journal Detail:
Title:  Current opinion in genetics & development     Volume:  22     ISSN:  1879-0380     ISO Abbreviation:  Curr. Opin. Genet. Dev.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-05-04     Completed Date:  2012-08-01     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9111375     Medline TA:  Curr Opin Genet Dev     Country:  England    
Other Details:
Languages:  eng     Pagination:  156-63     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
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MeSH Terms
RNA Interference*
RNA, Fungal / genetics*
RNA, Messenger / genetics
Schizosaccharomyces / genetics*
Grant Support
Z01 BC010523-04/BC/NCI NIH HHS; Z01 BC010523-05/BC/NCI NIH HHS; Z99 CA999999/CA/NCI NIH HHS; ZIA BC010523-07/BC/NCI NIH HHS; ZIA BC011208-01/BC/NCI NIH HHS; ZIA BC011208-02/BC/NCI NIH HHS; ZIA BC011208-03/BC/NCI NIH HHS
Reg. No./Substance:
0/Heterochromatin; 0/RNA, Fungal; 0/RNA, Messenger

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