Document Detail

Different magnesium sulphate regimens for neuroprotection of the fetus for women at risk of preterm birth.
MedLine Citation:
PMID:  22336863     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The effectiveness of antenatal magnesium sulphate for neuroprotection of the fetus, infant, and child prior to very preterm birth, when given to women considered at risk of preterm birth, has been established. There is currently no consensus as to the regimen to use in terms of the dose, duration, the use of repeat dosing and timing.
OBJECTIVES: To assess the comparative effectiveness and adverse effects of different magnesium sulphate regimens for neuroprotection of the fetus in women considered at risk of preterm birth.
SEARCH METHODS: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 December 2011).
SELECTION CRITERIA: Randomised trials comparing different magnesium sulphate regimens when used for neuroprotection of the fetus in women considered at risk of preterm birth. We planned to include cluster trials. We planned to exclude quasi-randomised trials and those with a crossover design. We planned to include trials published as full-text papers, along with those published in abstract form only.
DATA COLLECTION AND ANALYSIS: We planned that at least two review authors would assess trial eligibility.
MAIN RESULTS: No eligible completed trials were identified.
AUTHORS' CONCLUSIONS: Although strong evidence supports the use of antenatal magnesium sulphate for neuroprotection of the fetus prior to very preterm birth, no trials comparing different treatment regimens have been completed. Research should be directed towards comparisons of different dosages and other variations in regimens, evaluating both maternal and infant outcomes.
Emily Bain; Philippa Middleton; Caroline A Crowther
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-02-15
Journal Detail:
Title:  The Cochrane database of systematic reviews     Volume:  2     ISSN:  1469-493X     ISO Abbreviation:  Cochrane Database Syst Rev     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-16     Completed Date:  2012-05-23     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  100909747     Medline TA:  Cochrane Database Syst Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  CD009302     Citation Subset:  IM    
ARCH: Australian Research Centre for Health of Women and Babies, Discipline of Obstetrics and Gynaecology, The University of Adelaide, Adelaide, Australia.
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MeSH Terms
Magnesium Sulfate / therapeutic use*
Neuroprotective Agents / therapeutic use*
Premature Birth*
Reg. No./Substance:
0/Neuroprotective Agents; 7487-88-9/Magnesium Sulfate

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