Document Detail

Different levels of sensory neuropeptides (calcitonin gene-related peptide and substance P) during and after exercise in man.
MedLine Citation:
PMID:  8867778     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to investigate the regulation of two sensory peptides calcitonin gene-related peptide (CGRP) and substance P, reflected as circulating levels during provocation of the sympathetic nervous system. Levels in hypertensives, diabetics (NIDDM) and controls were assayed before, during and after an exercise test (average work load carried out was 76 +/- 10 kJ). CGRP levels increased progressively during exercise (P < 0.001), with maximum level at maximum exercise. This was significant in all three groups; hypertensives P < 0.001, diabetics P < 0.01 and controls P < 0.001. No differences in circulating revels of CGRP between the three groups were found. Substance P levels were fairly constant during exercise but increased 30 min after exercise (P < 0.01) in the total group. We hypothesize that CGRP might provide a counter-regulatory mechanism to the sympathetic vasoconstrictor transmitters noradrenaline (NA) and neuropeptide Y (NPY) during sympathetic activation. Substance P did not increase during exercise. This suggests differential regulation and function of the two vasodilatory peptides.
H Lind; L Brudin; L Lindholm; L Edvinsson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical physiology (Oxford, England)     Volume:  16     ISSN:  0144-5979     ISO Abbreviation:  Clin Physiol     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1997-01-03     Completed Date:  1997-01-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8309768     Medline TA:  Clin Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  73-82     Citation Subset:  IM    
Health Sciences Centre, Lund/Dalby, University of Lund, Sweden.
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MeSH Terms
Calcitonin Gene-Related Peptide / blood*
Exercise Test
Osmolar Concentration
Physical Exertion*
Substance P / blood*
Reg. No./Substance:
33507-63-0/Substance P; 83652-28-2/Calcitonin Gene-Related Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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