| Different inner retinal pathways mediate rod-cone input in irradiance detection for the pupillary light reflex and regulation of behavioral state in mice. | |
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MedLine Citation:
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PMID: 20847113 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Detection of light in the eye contributes both to spatial awareness (form vision) and to responses that acclimate an animal to gross changes in light (irradiance detection). This dual role means that eye disease that disrupts form vision can also adversely affect physiology and behavioral state. The purpose of this study was to investigate how inner retinal circuitry mediating rod-cone photoreceptor input contributes to functionally distinct irradiance responses and whether that might account for phenotypic diversity in retinal disease. METHODS: The sensitivity of the pupillary light reflex and negative masking (activity suppression by light) was measured in wild-type mice with intact inner retinal circuitry, Nob4 mice that lack ON-bipolar cell function, and rd1 mice that lack rods and cones and, therefore, have no input to ON or OFF bipolar cells. RESULTS: An expected increase in sensitivity to negative masking with loss of photoreceptor input in rd1 was duplicated in Nob4 mice. In contrast, sensitivity of the pupillary light reflex was more severely reduced in rd1 than in Nob4 mice. CONCLUSIONS: Absence of ON-bipolar cell-mediated rod-cone input can fully explain the phenotype of outer retina degeneration for negative masking but not for the pupillary light reflex. Therefore, inner retinal pathways mediating rod-cone input are different for negative masking and the pupillary light reflex. |
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Authors:
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Stewart Thompson; Steven F Stasheff; Jasmine Hernandez; Erik Nylen; Jade S East; Randy H Kardon; Lawrence H Pinto; Robert F Mullins; Edwin M Stone |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-02-01 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 52 ISSN: 1552-5783 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-02-02 Completed Date: 2011-03-09 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 618-23 Citation Subset: IM |
Affiliation:
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Howard Hughes Medical Institute, Universityof Iowa, Iowa City, Iowa 52242, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal* Light Male Mice Mice, Inbred C57BL Mice, Mutant Strains Motor Activity / physiology Reflex, Pupillary / physiology*, radiation effects Retinal Bipolar Cells / physiology* Retinal Cone Photoreceptor Cells / physiology, radiation effects* Retinal Degeneration / physiopathology* Retinal Ganglion Cells / physiology Retinal Rod Photoreceptor Cells / physiology, radiation effects* Vision, Ocular / physiology* Visual Perception |
| Grant Support | |
ID/Acronym/Agency:
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//Howard Hughes Medical Institute |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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