| Different immunosuppressive effects of liposomal FK506 in liver and kidney transplantation. | |
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MedLine Citation:
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PMID: 8623229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy of liposomal FK506 was compared between a canine liver transplantation model and a canine kidney transplantation model. The present study revealed that liposomal FK506 increased immunosuppressive efficacy of FK506 in liver transplantation but decreased in kidney transplantation. Because liposomal FK506 increased FK506 levels in the liver and spleen, and decreased FK506 levels in the kidney, it was suggested that enhanced immunosuppressive efficacy in liver transplantation should be attributed to the local immunosuppressive effects in the hepatic allograft rather than effective suppression of splenocyte activity. |
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Authors:
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S Ko; Y Nakajima; H Kanehiro; M Horikawa; A Yoshimura; K Kido; J Taki; Y Aomatsu; T Kin; K Yagura; T Ohyama; K Ohashi; T Yamada; H Nakano |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Transplantation proceedings Volume: 28 ISSN: 0041-1345 ISO Abbreviation: Transplant. Proc. Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-06-14 Completed Date: 1996-06-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1066-8 Citation Subset: IM |
Affiliation:
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First Department of Surgery, Nara Medical University, Kashihara, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Drug Carriers Female Graft Rejection / epidemiology, immunology Graft Survival / drug effects* Immunosuppressive Agents / administration & dosage*, therapeutic use Kidney Transplantation / immunology* Liposomes Liver Transplantation / immunology* Male Tacrolimus / administration & dosage*, therapeutic use Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Immunosuppressive Agents; 0/Liposomes; 109581-93-3/Tacrolimus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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