Document Detail

Different heritabilities but shared etiological influences for parent, teacher and self-ratings of ADHD symptoms: an adolescent twin study.
MedLine Citation:
PMID:  23298428     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Parent and teacher ratings of attention deficit hyperactivity disorder (ADHD) symptoms yield high estimates of heritability whereas self-ratings typically yield lower estimates. To understand why, the present study examined the etiological overlap between parent, teacher and self-ratings of ADHD symptoms in a population-based sample of 11-12-year-old twins. Method Participants were from the Twins Early Development Study (TEDS). ADHD symptoms were assessed using the Strengths and Difficulties Questionnaire (SDQ) hyperactivity scale completed by parents, teachers and children. Structural equation modeling was used to examine genetic and environmental contributions to phenotypic variance/covariance.
RESULTS: The broad-sense heritability of ADHD symptoms was 82% for parent ratings, 60% for teacher ratings and 48% for self-ratings. Post-hoc analyses revealed significantly higher heritability for same-teacher than different-teacher ratings of ADHD (76% v. 49%). A common pathway model best explained the relationship between different informant ratings, with common genetic influences accounting for 84% of the covariance between parent, teacher and self-rated ADHD symptoms. The remaining variance was explained by rater-specific genetic and non-shared environmental influences.
CONCLUSIONS: Despite different heritabilities, there were shared genetic influences for parent, teacher and self-ratings of ADHD symptoms, indicating that different informants rated some of the same aspects of behavior. The low heritability estimated for self-ratings and different-teacher ratings may reflect increased measurement error when different informants rate each twin from a pair, and/or greater non-shared environmental influences. Future studies into the genetic influences on ADHD should incorporate informant data in addition to self-ratings to capture a pervasive, heritable component of ADHD symptomatology.
A Merwood; C U Greven; T S Price; F Rijsdijk; J Kuntsi; G McLoughlin; H Larsson; P J Asherson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study     Date:  2013-01-09
Journal Detail:
Title:  Psychological medicine     Volume:  43     ISSN:  1469-8978     ISO Abbreviation:  Psychol Med     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-07     Completed Date:  2014-04-03     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1973-84     Citation Subset:  IM    
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MeSH Terms
Attention Deficit Disorder with Hyperactivity / genetics*,  psychology
Diseases in Twins*
Models, Genetic
Multivariate Analysis
Self Report*
Twins, Dizygotic / genetics,  psychology
Twins, Monozygotic / genetics,  psychology
Grant Support
G0500079//Medical Research Council; HD044454/HD/NICHD NIH HHS; R01 HD044454/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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