Document Detail


Different haplotypes for cystic fibrosis-linked DNA polymorphisms in Polish and Dutch populations.
MedLine Citation:
PMID:  2571559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We analyzed DNA from 34 Polish and 63 Dutch cystic fibrosis (CF) patients and their families using the polymorphic markers XV2c and KM19, which are in linkage disequilibrium with the CF mutation. Strong linkage disequilibrium was found in the Dutch population sample, but the haplotypes of the Polish chromosomes showed a significantly less extreme disequilibrium. Our data and previous studies indicate that the highest degree of homogeneity of the CF defect and hence the best possible use of the XV2c/KM19/CF linkage disequilibrium for CF carrier detection/exclusion is in populations of northern European origin.
Authors:
D Maciejko; J Bal; T Mazurczak; G te Meerman; C Buys; B Oostra; D Halley
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human genetics     Volume:  83     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-16     Completed Date:  1989-11-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  220-2     Citation Subset:  IM    
Affiliation:
National Research Institute of Mother and Child, Department of Genetics, Warsaw, Poland.
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MeSH Terms
Descriptor/Qualifier:
Cystic Fibrosis / genetics*
DNA / genetics*
Haplotypes*
Humans
Netherlands
Poland
Polymorphism, Restriction Fragment Length*
Chemical
Reg. No./Substance:
9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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