| Different functions of intestinal and liver-type fatty acid-binding proteins in intestine and in whole body energy homeostasis. | |
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MedLine Citation:
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PMID: 21350192 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has long been known that mammalian enterocytes coexpress two members of the fatty acid-binding protein (FABP) family, the intestinal FABP (IFABP) and the liver FABP (LFABP). Both bind long-chain fatty acids and have similar though not identical distributions in the intestinal tract. While a number of in vitro properties suggest the potential for different functions, the underlying reasons for expression of both proteins in the same cells are not known. Utilizing mice genetically lacking either IFABP or LFABP, we directly demonstrate that each of the enterocyte FABPs participates in specific pathways of intestinal lipid metabolism. In particular, LFABP appears to target fatty acids toward oxidative pathways and dietary monoacylglycerols toward anabolic pathways, while IFABP targets dietary fatty acids toward triacylglycerol synthesis. The two FABP-null models also displayed differences in whole body response to fasting, with LFABP-null animals losing less fat-free mass and IFABP-null animals losing more fat mass relative to wild-type mice. The metabolic changes observed in both null models appear to occur by nontranscriptional mechanisms, supporting the hypothesis that the enterocyte FABPs are specifically trafficking their ligands to their respective metabolic fates. |
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Authors:
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William Stacy Lagakos; Angela Marie Gajda; Luis Agellon; Bert Binas; Victor Choi; Bernadette Mandap; Timothy Russnak; Yin Xiu Zhou; Judith Storch |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-02-24 |
Journal Detail:
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Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 300 ISSN: 1522-1547 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-28 Completed Date: 2011-06-28 Revised Date: 2012-05-01 |
Medline Journal Info:
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Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: United States |
Other Details:
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Languages: eng Pagination: G803-14 Citation Subset: IM |
Affiliation:
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Department of Nutritional Sciences, Rutgers, the State University of New Jersey, New Brunswick, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blotting, Western Body Composition / genetics, physiology Body Weight / genetics, physiology Eating / genetics, physiology Energy Metabolism / physiology* Enterocytes / metabolism Fatty Acid-Binding Proteins / biosynthesis, genetics, physiology* Fatty Acids / metabolism Feces / chemistry Gene Expression / physiology Genotype Homeostasis / physiology Intestinal Mucosa / metabolism Intestines / metabolism*, physiology* Lipid Metabolism / genetics, physiology Lipids / blood Liver / metabolism*, physiology* Mice Mice, Inbred C57BL Mice, Knockout Oxidation-Reduction |
| Grant Support | |
ID/Acronym/Agency:
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DK-38389/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acid-Binding Proteins; 0/Fatty Acids; 0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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