Document Detail

Different expression of endothelin in the bronchoalveolar lavage in patients with pulmonary diseases.
MedLine Citation:
PMID:  11891606     Owner:  NLM     Status:  MEDLINE    
Endothelin (ET) is a broncho- and vasoconstrictive cytokine, but it also possesses proinflammatory and mitogenic activity. It is suggested to be involved in the pathogenesis of fibrotic lung diseases. We analyzed the concentration of ET 1 in the bronchoalveolar lavage (BAL) fluid in 95 patients with different lung diseases, among them 41 patients with interstitial lung diseases (13 fibrosing alveolitis in systemic sclerosis (FASS), 9 idiopathic pulmonary fibrosis (IFP), 8 sarcoidosis (S), 6 occupational lung disease (OLD), 5 other alveolitidies A), 27 patients with pneumonia, and 8 patients with chronic obstructive pulmonary disease (COPD). A heterogeneous group of 19 patients served as controls. The median ET concentration was 3.3 pg/ml. Significantly higher concentration was found in patients with FASS (5.8 pg/ml), IPF (5.0 pg/ml), and S (5.1 pg/ml) compared with OLD (2.8 pg/ml), A (1.9 pg/ml), COPD (1.5 pg/ml), and the control group (2.5 pg/ml). In pneumonia, the elevated ET concentration (4.1 pg/ml) was accompanied by a high alveolocapillary leakage. When normalized to BAL albumin concentration, only FASS presented with significantly elevated ET/albumin in the BAL compared with the control group (134.5 vs. 56.l pg/mg, p < 0.05). There were no correlations between ET and BAL differential cell count or pulmonary function tests. In current smokers, ET in BALF was significantly higher compared with non- or ex-smokers (3.9 vs. 2.0 pg/ml, p < 0.01), but not so the ET/albumin ratio (65.0 vs. 62.5 pg/mg). In summary, ET in the BAL is differentially expressed in distinct inflammatory and interstitial lung disease. Consistently high concentrations are found in FASS and elevated ET concentration could be discussed in IPF, sarcoidosis, and pneumonia. ET concentration in BAL is influenced by current smoking habits.
F Reichenberger; J Schauer; K Kellner; U Sack; P Stiehl; J Winkler
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2002-02-04
Journal Detail:
Title:  Lung     Volume:  179     ISSN:  0341-2040     ISO Abbreviation:  Lung     Publication Date:  2001  
Date Detail:
Created Date:  2002-03-13     Completed Date:  2002-04-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  163-74     Citation Subset:  IM    
Division of Pneumology, Department of Internal Medicine, University Hospital, Johannisalle 32, 04105 Leipzig, Germany.
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MeSH Terms
Albumins / analysis
Biological Markers / analysis
Bronchoalveolar Lavage Fluid / chemistry*,  cytology*
Endothelins / biosynthesis*
Germany / epidemiology
Lung Diseases / etiology,  metabolism*
Middle Aged
Prospective Studies
Pulmonary Fibrosis / etiology
Respiratory Function Tests
Smoking / adverse effects
Reg. No./Substance:
0/Albumins; 0/Biological Markers; 0/Endothelins

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