Document Detail

Different effects of white and red wine on lower esophageal sphincter pressure and gastroesophageal reflux.
MedLine Citation:
PMID:  9517519     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: White wine and beer induce gastroesophageal reflux (GER). We investigated the effects of white and red wine on lower esophageal sphincter pressure (LESP) and GER. METHODS: Twenty healthy volunteers received 300 ml white wine, red wine, or water together with a standardized meal. The LESP was continuously monitored with a Dent sleeve the 1st h postprandially, and the esophageal pH measured with a glass pH electrode. RESULTS: The LESP was decreased after intake of white wine (median, 14.9 mmHg; range, 5.6-19.5 mmHg) compared with red wine (20.4 mmHg; 13.1-22.3 mmHg; P < 0.05) and tap water (19.5 mmHg; 16.2-29.1 mmHg; P < 0.01). The fraction time esophageal pH <4 was increased after both alcoholic beverages compared with tap water (0.9%; 0.2-5.8%; P < 0.01 versus white wine, P < 0.05 versus red wine) with a greater fraction time after white wine (13.2; 0.3-58.1 ) than after red wine (2.3; 0.7-24.4; P < 0.05). The decreased sphincter pressure after white wine was accompanied by a change in the reflux pattern with increased 'stress reflux' and the occurrence of 'free reflux'. CONCLUSION: White wine and red wine exert different effects on LESP and GER.
C Pehl; A Pfeiffer; B Wendl; H Kaess
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  33     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-05-12     Completed Date:  1998-05-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  118-22     Citation Subset:  IM    
Dept. of Gastroenterology and Hepatology, Hospital Bogenhausen, Munich, Germany.
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MeSH Terms
Esophagogastric Junction / drug effects,  physiology*
Esophagus / drug effects,  physiology
Gastroesophageal Reflux / chemically induced*
Hydrogen-Ion Concentration
Middle Aged
Peristalsis / drug effects
Wine / adverse effects*

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