Document Detail

Different effects of metoprolol and chlorthalidone on serum lipoprotein levels in mild hypertension. Possible implications for coronary heart disease risk status.
MedLine Citation:
PMID:  6519949     Owner:  NLM     Status:  MEDLINE    
The effects of chlorthalidone and metoprolol on fasting plasma lipids and lipoprotein levels were compared in two similar nonrandomized groups of patients with mild hypertension. Chlorthalidone therapy was associated with an increase in serum cholesterol of 8.1% (17 mg/dl), mainly reflecting an increase in low-density lipoprotein (LDL)-cholesterol. High-density lipoproteins (HDL)-cholesterol decreased, but the difference between pre- and posttreatment levels did not reach statistical significance. Serum triglyceride (TG) concentration increased by 16% (20 mg/dl). Metoprolol therapy was not associated with changes in total, very low-density lipoprotein (VLDL)-, LDL- and HDL-cholesterol levels. Serum TG concentration increased by 22% (28 mg/dl), mainly due to an increase in VLDL-TG. Application of the Israel Ischemic Heart Disease Study data to these findings could predict only a very slight decrease in the 5-year estimated probability of myocardial infarction in the chlorthalidone-treated group. Metoprolol therapy has, theoretically, a more favorable influence on coronary heart disease risk status. These data suggest that the different forms of therapy for mild hypertension have a different effect on the theoretical coronary heart disease risk status, a fact that should be taken into consideration in the choice of medication.
E Holtzman; T Rosenthal; U Goldbourt; P Segal
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Israel journal of medical sciences     Volume:  20     ISSN:  0021-2180     ISO Abbreviation:  Isr. J. Med. Sci.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-02-25     Completed Date:  1985-02-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0013105     Medline TA:  Isr J Med Sci     Country:  ISRAEL    
Other Details:
Languages:  eng     Pagination:  1169-76     Citation Subset:  IM    
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MeSH Terms
Body Weight
Chlorthalidone / adverse effects*
Cholesterol / blood
Coronary Disease / etiology*
Heart Rate
Hypertension / blood,  drug therapy*
Lipoproteins / blood*
Metoprolol / adverse effects*
Middle Aged
Triglycerides / blood
Reg. No./Substance:
0/Lipoproteins; 0/Triglycerides; 37350-58-6/Metoprolol; 57-88-5/Cholesterol; 77-36-1/Chlorthalidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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