| Different effects of hypertension, atherosclerosis and hyperlipidaemia on arterial distensibility. | |
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MedLine Citation:
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PMID: 8903638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the different effects of hypertension, hyperlipidaemia and atherosclerosis on the visco-elastic properties of large arteries. DESIGN: Vessel wall properties were determined in patients who had been subjected for the first time to coronary arteriography. Normotensive patients with no coronary disease (n = 15), one-vessel disease (n = 15) or two- or three-vessel disease (n = 15), 15 treated hypertensive patients (mean +/- SEM duration of hypertension 9.6 +/- 1.7 years) with no coronary disease and normocholesterolaemia and 15 healthy controls were matched for blood pressure, age and sex. METHODS: Arterial distension of the common carotid artery was determined by using a multigate Doppler system. The blood pressure curve was recorded by finger plethysmography. RESULTS: The end-diastolic diameter was significantly higher in the hypertensives (P<0.05) but not significantly different in the normotensives compared with the controls. Arterial distensibility was significantly lower in the hypertensive group [(13.3 +/- 0.8) x 10(-3)/kPa] than in the controls [(19.1 +/- 1.5) x 10(-3)/kP; P<0.01), in the group with no coronary disease [(18.8 +/- 1.3) x 10(-3)/kPa; P<0.01] and in those with one-vessel disease [(17.7 +/- 1.4) x 10(-3)/kPa; P<0.05]. Arterial distensibility was not significantly lower in the hypertensives than in the group with two- or three-vessel disease [(15.0 +/- 1.0) x 10(-3)/kPa; NS). No significant correlation was found between cholesterol or lipoprotein(a) levels and arterial distensibility in the normotensive patients. CONCLUSIONS: Hypertension is the predominant factor affecting the visco-elastic properties of large arteries. Arterial compliance is significantly altered only in extensive atherosclerosis. |
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Authors:
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M Barenbrock; C Spieker; S Kerber; C Vielhauer; A P Hoeks; W Zidek; K H Rahn |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of hypertension Volume: 13 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1997-03-19 Completed Date: 1997-03-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1712-7 Citation Subset: IM |
Affiliation:
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Department of Medicine D, University of Munster, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arteriosclerosis
/
blood,
diagnosis,
physiopathology* Blood Pressure Carotid Arteries / ultrasonography* Cholesterol / blood* Coronary Angiography Humans Hyperlipidemias / blood, diagnosis, physiopathology* Hypertension / blood, diagnosis, physiopathology* Lipoprotein(a) / blood* Middle Aged Plethysmography |
| Chemical | |
Reg. No./Substance:
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0/Lipoprotein(a); 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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