Document Detail

Different effects of dronedarone and amiodarone on pulmonary vein electrophysiology, mechanical properties and H(2)O(2)-induced arrhythmogenicity.
MedLine Citation:
PMID:  23376158     Owner:  NLM     Status:  Publisher    
Dronedarone and amiodarone are anti-atrial fibrillation agents with different potency. Pulmonary veins play a critical role in the genesis of atrial fibrillation. Oxidative stress can enhance pulmonary vein arrhythmogenesis. This study was done to compare the effects of dronedarone and amiodarone on pulmonary vein electrophysiological and mechanical properties, and oxidative stress-induced arrhythmogenecity. Conventional microelectrodes were used to record action potentials in isolated rabbit pulmonary vein specimens before and after dronedarone and amiodarone with or without the presence of H2O2 (2mM). Dronedarone (0.1, 1 and 10μM) concentration-dependently decreased pulmonary vein beating rates (from 2.2±0.1 to 1.9±0.1, 1.8±0.1 and 1.7±0.1Hz, n=8, P<0.01). Amiodarone (0.1, 1 and 10μM) also concentration-dependently decreased pulmonary vein beating rates (from 2.5±0.2 to 2.3±0.2, 2.2±0.2 and 2.0±0.2Hz, n=7, P<0.01). However, dronedarone decreased pulmonary vein beating rates to a greater extent at 0.1μM (12% versus 4%, P< 0.005) and 1μM (17% versus 9%, P< 0.005). Dronedarone or amiodarone (0.1, 1 and 10μM) did not change the pulmonary vein contractility. However, dronedarone (1 and 10μM) concentration-dependently reduced pulmonary vein diastolic tension by 13±2mg (P< 0.005) and 18±3mg (P<0.005). In contrast, amiodarone did not change pulmonary vein diastolic tension. Dronedarone (10μM) and amiodarone (10μM) attenuated H2O2-induced pulmonary vein burst firings from 100% to 33.3% (P<0.01), and to 0% (P<0.005), respectively. In conclusion, amiodarone and dronedarone both significantly reduced pulmonary vein spontaneous beating rates and H2O2-induced pulmonary vein arrhythmogenesis. However, only dronedarone produced pulmonary vein vasodilation.
Dicky Armein Hanafy; Yao-Chang Chen; Shih-Lin Chang; Yen-Yu Lu; Yung-Kuo Lin; Yu-Hsun Kao; Shih-Ann Chen; Yi-Jen Chen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-31
Journal Detail:
Title:  European journal of pharmacology     Volume:  -     ISSN:  1879-0712     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-2-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier B.V.
Division of Cardiology and Cardiovascular Research Center, Veterans General Hospital-Taipei, Taipei, Taiwan.
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