Document Detail

Different effectors of dimorphism in Yarrowia lipolytica.
MedLine Citation:
PMID:  12420169     Owner:  NLM     Status:  MEDLINE    
Yarrowia lipolytica is an ascomycete with biotechnological potential. In common media, the fungus grows as a mixture of yeast-like and short mycelial cells. The environmental factors that affect dimorphism in the wild-type strain, W29, and its auxotrophic derivative, PO1a, were analyzed. In both strains, pH was the most important factor regulating the dimorphic transition. Mycelium formation was maximal at pH near neutrality and decreased as pH was lowered to become almost null at pH 3. Carbon and nitrogen sources, namely glucose and ammonium, were also important for mycelium formation; and their effect was antagonized by some alternative carbon and nitrogen sources. Citrate was an important positive effector of mycelium growth. Anaerobic stress induced formation of mycelial cells. The importance of the protein kinase A pathway was suggested by the inhibition of mycelium growth by cAMP. We propose that the interplay of these factors regulates the adaptation of the fungus, to better exploit its natural ecological niches.
José Ruiz-Herrera; Rafael Sentandreu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2002-10-15
Journal Detail:
Title:  Archives of microbiology     Volume:  178     ISSN:  0302-8933     ISO Abbreviation:  Arch. Microbiol.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-06     Completed Date:  2003-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0410427     Medline TA:  Arch Microbiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  477-83     Citation Subset:  IM    
Departamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del IPN, Irapuato, Guanajuato, Mexico.
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MeSH Terms
Carbon / metabolism
Citric Acid / metabolism
Culture Media
Cyclic AMP / pharmacology
Hot Temperature
Hydrogen-Ion Concentration
Nitrogen / chemistry,  metabolism*
Sex Characteristics*
Yarrowia / cytology,  drug effects,  growth & development,  physiology*
Reg. No./Substance:
0/Culture Media; 60-92-4/Cyclic AMP; 7440-44-0/Carbon; 77-92-9/Citric Acid; 7727-37-9/Nitrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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